Next Article in Journal
New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis
Next Article in Special Issue
Towards the Enhancement of Essential Oil Components’ Antimicrobial Activity Using New Zein Protein-Gated Mesoporous Silica Microdevices
Previous Article in Journal
The Association of Human Herpesviruses with Malignant Brain Tumor Pathology and Therapy: Two Sides of a Coin
Previous Article in Special Issue
Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant
Article

Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy

1
Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan
2
Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori 590-0494, Japan
3
Center for Innovative Materials and Architectures (INOMAR), Vietnam National University, Ho Chi Minh City 721337, Vietnam
4
TAE Lifesciences, Drug Development Division, Santa Monica, CA 90404, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Andrea Salis
Int. J. Mol. Sci. 2021, 22(5), 2251; https://doi.org/10.3390/ijms22052251
Received: 10 December 2020 / Revised: 19 February 2021 / Accepted: 21 February 2021 / Published: 24 February 2021
(This article belongs to the Special Issue Ordered Mesoporous Materials)
Biodegradable periodic mesoporous organosilica (BPMO) has recently emerged as a promising type of mesoporous silica-based nanoparticle for biomedical applications. Like mesoporous silica nanoparticles (MSN), BPMO possesses a large surface area where various compounds can be attached. In this work, we attached boronophenylalanine (10BPA) to the surface and explored the potential of this nanomaterial for delivering boron-10 for use in boron neutron capture therapy (BNCT). This cancer therapy is based on the principle that the exposure of boron-10 to thermal neutron results in the release of α-particles that kill cancer cells. To attach 10BPA, the surface of BPMO was modified with diol groups which facilitated the efficient binding of 10BPA, yielding 10BPA-loaded BPMO (10BPA-BPMO). Surface modification with phosphonate was also carried out to increase the dispersibility of the nanoparticles. To investigate this nanomaterial’s potential for BNCT, we first used human cancer cells and found that 10BPA-BPMO nanoparticles were efficiently taken up into the cancer cells and were localized in perinuclear regions. We then used a chicken egg tumor model, a versatile and convenient tumor model used to characterize nanomaterials. After observing significant tumor accumulation, 10BPA-BPMO injected chicken eggs were evaluated by irradiating with neutron beams. Dramatic inhibition of the tumor growth was observed. These results suggest the potential of 10BPA-BPMO as a novel boron agent for BNCT. View Full-Text
Keywords: biodegradable periodic mesoporous organosilica; boronophenylalanine; boron neutron capture therapy; cancer cells; chicken egg tumor model biodegradable periodic mesoporous organosilica; boronophenylalanine; boron neutron capture therapy; cancer cells; chicken egg tumor model
Show Figures

Figure 1

MDPI and ACS Style

Tamanoi, F.; Chinnathambi, S.; Laird, M.; Komatsu, A.; Birault, A.; Takata, T.; Doan, T.L.-H.; Mai, N.X.D.; Raitano, A.; Morrison, K.; Suzuki, M.; Matsumoto, K. Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy. Int. J. Mol. Sci. 2021, 22, 2251. https://doi.org/10.3390/ijms22052251

AMA Style

Tamanoi F, Chinnathambi S, Laird M, Komatsu A, Birault A, Takata T, Doan TL-H, Mai NXD, Raitano A, Morrison K, Suzuki M, Matsumoto K. Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy. International Journal of Molecular Sciences. 2021; 22(5):2251. https://doi.org/10.3390/ijms22052251

Chicago/Turabian Style

Tamanoi, Fuyuhiko, Shanmugavel Chinnathambi, Mathilde Laird, Aoi Komatsu, Albane Birault, Takushi Takata, Tan L.-H. Doan, Ngoc X.D. Mai, Arthur Raitano, Kendall Morrison, Minoru Suzuki, and Kotaro Matsumoto. 2021. "Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy" International Journal of Molecular Sciences 22, no. 5: 2251. https://doi.org/10.3390/ijms22052251

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop