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Review

Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

Department of Biomedical Engineering, University of North Texas, Denton, TX 76203, USA
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Author to whom correspondence should be addressed.
Academic Editor: Nicola Veronese
Int. J. Mol. Sci. 2021, 22(4), 1742; https://doi.org/10.3390/ijms22041742
Received: 8 January 2021 / Revised: 2 February 2021 / Accepted: 4 February 2021 / Published: 9 February 2021
(This article belongs to the Special Issue Osteoarthritis: From Molecular Pathways to Therapeutic Advances)
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA. However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions available to restore degraded cartilage. This review fully illustrates the involvement of MMP-13 in the initiation and progression of OA through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA. View Full-Text
Keywords: osteoarthritis; cartilage; type II collagen; matrix metalloproteinases; MMP-13; regulation; inhibitor osteoarthritis; cartilage; type II collagen; matrix metalloproteinases; MMP-13; regulation; inhibitor
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MDPI and ACS Style

Hu, Q.; Ecker, M. Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis. Int. J. Mol. Sci. 2021, 22, 1742. https://doi.org/10.3390/ijms22041742

AMA Style

Hu Q, Ecker M. Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis. International Journal of Molecular Sciences. 2021; 22(4):1742. https://doi.org/10.3390/ijms22041742

Chicago/Turabian Style

Hu, Qichan, and Melanie Ecker. 2021. "Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis" International Journal of Molecular Sciences 22, no. 4: 1742. https://doi.org/10.3390/ijms22041742

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