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Bioactive Lipids in MSCs Biology: State of the Art and Role in Inflammation

1
Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, 20133 Milan, Italy
2
IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Gabriella Calviello
Int. J. Mol. Sci. 2021, 22(3), 1481; https://doi.org/10.3390/ijms22031481
Received: 15 January 2021 / Revised: 28 January 2021 / Accepted: 29 January 2021 / Published: 2 February 2021
(This article belongs to the Section Biochemistry)
Lipidomics is a lipid-targeted metabolomics approach that aims to the comprehensive analysis of lipids in biological systems in order to highlight the specific functions of lipid species in health and disease. Lipids play pivotal roles as they are major structural components of the cellular membranes and energy storage molecules but also, as most recently shown, they act as functional and regulatory components of intra- and intercellular signaling. Herein, emphasis is given to the recently highlighted roles of specific bioactive lipids species, as polyunsaturated fatty acids (PUFA)-derived mediators (generally known as eicosanoids), endocannabinoids (eCBs), and lysophospholipids (LPLs), and their involvement in the mesenchymal stem cells (MSCs)-related inflammatory scenario. Indeed, MSCs are a heterogenous population of multipotent cells that have attracted much attention for their potential in regulating inflammation, immunomodulatory capabilities, and reparative roles. The lipidomics of the inflammatory disease osteoarthritis (OA) and the influence of MSCs-derived lipids have also been addressed. View Full-Text
Keywords: bioactive lipids; lipidomics; mesenchymal stem cells; inflammation; osteoarthritis bioactive lipids; lipidomics; mesenchymal stem cells; inflammation; osteoarthritis
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MDPI and ACS Style

Casati, S.; Giannasi, C.; Niada, S.; Bergamaschi, R.F.; Orioli, M.; Brini, A.T. Bioactive Lipids in MSCs Biology: State of the Art and Role in Inflammation. Int. J. Mol. Sci. 2021, 22, 1481. https://doi.org/10.3390/ijms22031481

AMA Style

Casati S, Giannasi C, Niada S, Bergamaschi RF, Orioli M, Brini AT. Bioactive Lipids in MSCs Biology: State of the Art and Role in Inflammation. International Journal of Molecular Sciences. 2021; 22(3):1481. https://doi.org/10.3390/ijms22031481

Chicago/Turabian Style

Casati, Sara, Chiara Giannasi, Stefania Niada, Roberta F. Bergamaschi, Marica Orioli, and Anna T. Brini. 2021. "Bioactive Lipids in MSCs Biology: State of the Art and Role in Inflammation" International Journal of Molecular Sciences 22, no. 3: 1481. https://doi.org/10.3390/ijms22031481

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