The Relevance of G-Quadruplexes for DNA Repair
Abstract
:1. Introduction
1.1. Homologous Recombination (HR)
1.2. Non-Homologous End Joining (NHEJ)
1.3. Base Excision Repair (BER)
1.4. Nucleotide Excision Repair (NER)
1.5. Mismatch Repair (MMR)
1.6. Translesion Synthesis (TLS)
2. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Pathway | Protein | Function at G4s | Organism | REFs |
---|---|---|---|---|
HR | EXO1 | Binding and unwinding * | Human | [69] |
DNA2 | Binding and unwinding | Human/yeast | [67,70] | |
Rad50 | Binding * | Human | [71,72] | |
Rad51 | Necessary for G4-mediated DNA damage | Human | [73] | |
BRCA1 | Binding | Human | [74] | |
BRCA2 | Necessary for G4-mediated DNA damage | Human | [75] | |
Mre11 | Binding | Yeast | [66,71] | |
NHEJ | Ku70 | Binding | Human | [76,77,78] |
Ku80 | Binding | Human | [76,77] | |
PARP3 | Affecting G4 levels | Human | [79] | |
AID | Binding | Human | [80,81,82] | |
PARP1 | Binding | Human | [78,83] | |
BER | OGG1 | Supporting formation | Human | [84] |
APE1 | Supporting formation | Human | [84,85] | |
PARP1 | Binding | Human | [78,83] | |
NER | Rad23 | Binding * | Yeast | [86] |
CSB | Binding and resolving | Human | [87] | |
XAB2 | Binding * | Human | [71] | |
XPD | Binding and unwinding | Human | [88] | |
XPB | Binding | Human | [88] | |
RPA | Binding, preventing formation, unfolding | Human | [68,89,90,91,92] | |
DDB2 | Binding * | Human | [78] | |
Zuo1 | Binding and stabilizing | Yeast | [86] | |
MMR | MutS | Binding | Bacteria | [93,94] |
MutL | Binding | Bacteria | [93] | |
MSH2 | Binding | Human | [95] | |
MSH6 | Binding | Human | [95] | |
MSH4 | Binding * | Human | [78] | |
Exo1 | Binding and unwinding * | Human | [69] | |
TLS | Pol η | Replicating past G4s | Human | [96] |
Pol κ | Replicating past G4s | Human | [96] | |
REV1 | Binding, preventing refolding | Human | [97,98] | |
Pol θ | Preventing deletions at G4s | Human | [99] | |
Helicases | WRN | Unwinding | Human | [71,100,101] |
FANCJ | Unwinding | Human | [39] | |
BLM | Binding and unwinding | Human | [61,102] | |
Pif1 | Binding and unwinding | Yeast | [17,40] |
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Linke, R.; Limmer, M.; Juranek, S.A.; Heine, A.; Paeschke, K. The Relevance of G-Quadruplexes for DNA Repair. Int. J. Mol. Sci. 2021, 22, 12599. https://doi.org/10.3390/ijms222212599
Linke R, Limmer M, Juranek SA, Heine A, Paeschke K. The Relevance of G-Quadruplexes for DNA Repair. International Journal of Molecular Sciences. 2021; 22(22):12599. https://doi.org/10.3390/ijms222212599
Chicago/Turabian StyleLinke, Rebecca, Michaela Limmer, Stefan A. Juranek, Annkristin Heine, and Katrin Paeschke. 2021. "The Relevance of G-Quadruplexes for DNA Repair" International Journal of Molecular Sciences 22, no. 22: 12599. https://doi.org/10.3390/ijms222212599