Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease
Abstract
:1. Introduction
2. The Notch Signalling Pathway
3. 3D Culture Systems
3.1. Spheroids
3.2. Organoids
3.3. “Organ-on-a-chip” Technology
4. Modelling the 3D Microenvironment
5. 3D Systems in Regenerative Medicine
6. 3D Cultures in Disease Modelling
7. Drug Screening and Therapy Testing in 3D Culture Systems
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
NICD | Notch Intracellular Domain |
Dll4 | Delta-like4 |
3D | Three-dimensional |
EBs | Embryoid Bodies |
PSCs | Pluripotent Stem Cells |
MSCs | Mesenchymal Stem Cells |
HIF1 | Hypoxia inducible factor 1 |
ASCs | Adult Stem Cells |
ECM | Extracellular Matrix |
ESCs | Embryonic Stem Cells |
iPSC | Induced-Pluripotent Stem Cells |
TNF | Tumour Necrosis Factor |
IL1 | Interleukin-1 |
NGS | Next Generation Sequencing |
DSCs | Dental Stem Cells |
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Marconi, G.D.; Porcheri, C.; Trubiani, O.; Mitsiadis, T.A. Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease. Int. J. Mol. Sci. 2021, 22, 12473. https://doi.org/10.3390/ijms222212473
Marconi GD, Porcheri C, Trubiani O, Mitsiadis TA. Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease. International Journal of Molecular Sciences. 2021; 22(22):12473. https://doi.org/10.3390/ijms222212473
Chicago/Turabian StyleMarconi, Guya Diletta, Cristina Porcheri, Oriana Trubiani, and Thimios A. Mitsiadis. 2021. "Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease" International Journal of Molecular Sciences 22, no. 22: 12473. https://doi.org/10.3390/ijms222212473