Next Article in Journal
Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks
Next Article in Special Issue
Connexin46 Expression Enhances Cancer Stem Cell and Epithelial-to-Mesenchymal Transition Characteristics of Human Breast Cancer MCF-7 Cells
Previous Article in Journal
DNA Repair in Haploid Context
Previous Article in Special Issue
Extracellular Vesicles and Cancer Stem Cells in Tumor Progression: New Therapeutic Perspectives
Review

MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy

1
Department of Onco-Haematology, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy
2
Department of Laboratory Medicine, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy
3
Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
4
Department of Surgery Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
5
Anatomic Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
6
Institut National de la Sante et de la Recherche Medicale (INSERM), UMR-S 1076, Aix-Marseille University, UFR Pharmacy, 13005 Marseille, France
*
Author to whom correspondence should be addressed.
Academic Editor: Evgeny Imyanitov
Int. J. Mol. Sci. 2021, 22(22), 12416; https://doi.org/10.3390/ijms222212416
Received: 13 October 2021 / Revised: 9 November 2021 / Accepted: 10 November 2021 / Published: 17 November 2021
(This article belongs to the Special Issue Cancer Cell Invasion and Metastases 2.0)
Human malignant melanoma shows a high rate of mortality after metastasization, and its incidence is continuously rising worldwide. Several studies have suggested that MCAM/MUC18/CD146 plays an important role in the progression of this malignant disease. MCAM/MUC18/CD146 is a typical single-spanning transmembrane glycoprotein, existing as two membrane isoforms, long and short, and an additional soluble form, sCD146. We previously documented that molecular MCAM/MUC18/CD146 expression is strongly associated with disease progression. Recently, we showed that MCAM/MUC18/CD146 and ABCB5 can serve as melanoma-specific-targets in the selection of highly primitive circulating melanoma cells, and constitute putative proteins associated with disease spreading progression. Here, we analyzed CD146 molecular expression at onset or at disease recurrence in an enlarged melanoma case series. For some patients, we also performed the time courses of molecular monitoring. Moreover, we explored the role of soluble CD146 in different cohorts of melanoma patients at onset or disease progression, rather than in clinical remission, undergoing immune therapy or free from any clinical treatment. We showed that MCAM/MUC18/CD146 can be considered as: (1) a membrane antigen suitable for identification and enrichment in melanoma liquid biopsy; (2) a highly effective molecular “warning” marker for minimal residual disease monitoring; and (3) a soluble protein index of inflammation and putative response to therapeutic treatments. View Full-Text
Keywords: MCAM/MUC18/CD146; soluble CD146; liquid biopsy; circulating melanoma cells (CMCs); gene-expression panel MCAM/MUC18/CD146; soluble CD146; liquid biopsy; circulating melanoma cells (CMCs); gene-expression panel
Show Figures

Figure 1

MDPI and ACS Style

Rapanotti, M.C.; Cugini, E.; Nuccetelli, M.; Terrinoni, A.; Di Raimondo, C.; Lombardo, P.; Costanza, G.; Cosio, T.; Rossi, P.; Orlandi, A.; Campione, E.; Bernardini, S.; Blot-Chabaud, M.; Bianchi, L. MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy. Int. J. Mol. Sci. 2021, 22, 12416. https://doi.org/10.3390/ijms222212416

AMA Style

Rapanotti MC, Cugini E, Nuccetelli M, Terrinoni A, Di Raimondo C, Lombardo P, Costanza G, Cosio T, Rossi P, Orlandi A, Campione E, Bernardini S, Blot-Chabaud M, Bianchi L. MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy. International Journal of Molecular Sciences. 2021; 22(22):12416. https://doi.org/10.3390/ijms222212416

Chicago/Turabian Style

Rapanotti, Maria C., Elisa Cugini, Marzia Nuccetelli, Alessandro Terrinoni, Cosimo Di Raimondo, Paolo Lombardo, Gaetana Costanza, Terenzio Cosio, Piero Rossi, Augusto Orlandi, Elena Campione, Sergio Bernardini, Marcel Blot-Chabaud, and Luca Bianchi. 2021. "MCAM/MUC18/CD146 as a Multifaceted Warning Marker of Melanoma Progression in Liquid Biopsy" International Journal of Molecular Sciences 22, no. 22: 12416. https://doi.org/10.3390/ijms222212416

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop