BP180/Collagen XVII: A Molecular View
Abstract
:1. Introduction
2. Structure of BP180
3. Expression of BP180
4. Post-Translational Modifications of BP180
5. BP180 Ectodomain Shedding
6. Protein–Protein Interactions of BP180
7. The Role of BP180 in Cell Migration, Proliferation, and Differentiation
8. Mechanisms and Consequences of BP180 Downregulation
Molecular Defects | References [3,11,45,47,52,53,110,111,124,136,137,138,139,140,141,142] | |
Hereditary blistering skin diseases
| Recessive missense and nonsense mutation in several sites in COL17A1 | Bauer and Lanschuetzer, 2003 Kiritsi et al., 2011 Huber et al., 2002 Has et al., 2019 |
Autoimmune skin diseases
| IgG, IgE, IgA autoantibodies against the NC16A immune-dominant domain of BP180 and other epitopes located in the ICD, Col15 domain, and C-terminus | Bağcı et al., 2017 Xu et al., 2013 Kamaguchi and Iwata, 2019 Solano-Lopez et al., 2015 Huilaja et al., 2014 Cozzani et al., 2020 |
Cancer
| Altered expression of BP180 Altered shedding of BP180 | Moilanen et al., 2015, 2017 Parikka et al., 2001 Liu et al., 2016a,b Krenacs et al., 2012 |
9. BP180 in Health and Diseases—Future Views
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tuusa, J.; Kokkonen, N.; Tasanen, K. BP180/Collagen XVII: A Molecular View. Int. J. Mol. Sci. 2021, 22, 12233. https://doi.org/10.3390/ijms222212233
Tuusa J, Kokkonen N, Tasanen K. BP180/Collagen XVII: A Molecular View. International Journal of Molecular Sciences. 2021; 22(22):12233. https://doi.org/10.3390/ijms222212233
Chicago/Turabian StyleTuusa, Jussi, Nina Kokkonen, and Kaisa Tasanen. 2021. "BP180/Collagen XVII: A Molecular View" International Journal of Molecular Sciences 22, no. 22: 12233. https://doi.org/10.3390/ijms222212233