Epigenetic Regulation of Endothelial Dysfunction and Inflammation in Pulmonary Arterial Hypertension
Abstract
:1. Introduction
2. Endothelial Dysfunction
3. Epigenetic Regulation of Endothelial Function
4. PAMPs and DAMPs
5. Central Pathways Driving Inflammation
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Source | Epigenetic Regulators | Primary Model | Description: | |
---|---|---|---|---|
DNA methylation | Chan et al. (2004) [33] | multiple | mice | eNOS expression |
Fish et al. (2005) [34] | multiple | in vitro | eNOS expression | |
Quentmeier et al. (2012) [46] | multiple | in vitro | angiogenesis | |
Hautefort et al. (2017) [62] | multiple | in vitro | proliferation; EnMT, inflammation | |
Wang et al. (2018) [49] | N/A | patients | vascular remodeling | |
Ke et al. (2018) [87] | Specificity Protein 1 | in vitro/lamb | eNOS expression | |
Yan et al. (2020) [45] | DNMT3B | rat | vascular remodeling | |
Joshi et al. (2020) [48] | multiple | mice | mitochondrial metabolism | |
Histone modifications | Maleszewska et al. (2016) [55] | EZH2 | in vitro | EC expression |
Hulshoff et al. (2018) [89] | multiple | in vitro | EnMT | |
Li et al. (2018) [94] | JARID1B | in vitro | proliferation | |
Yan et al. (2018) [60] | KAT7 | zebrafish | angiogenesis | |
Yu et al. (2019) [92] | BOLA3 | in vitro | EC metabolism | |
Non-coding RNAs | Michalik et al. (2014) [75] | MALAT1 | in vitro | proliferation |
Simion et al. (2019) [72] | multiple | in vitro | angiogenesis | |
Puthanveetil et al. (2015) [74] | MALAT1 | in vitro/mice | inflammation | |
Rosano et al. (2020) [70] | miR-424-5p, miR-29a-3p | in vitro | EC expression | |
Sindi et al. (2020) [71] | miR-181a-5p, miR-324-5p | in vitro | proliferation; angiogenesis | |
Liu et al. (2020) [76] | ANRIL | patients | EC dysfunction | |
Bian et al. (2021) [77] | NORAD | in vitro | proliferation; EnMT |
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Hudson, J.; Farkas, L. Epigenetic Regulation of Endothelial Dysfunction and Inflammation in Pulmonary Arterial Hypertension. Int. J. Mol. Sci. 2021, 22, 12098. https://doi.org/10.3390/ijms222212098
Hudson J, Farkas L. Epigenetic Regulation of Endothelial Dysfunction and Inflammation in Pulmonary Arterial Hypertension. International Journal of Molecular Sciences. 2021; 22(22):12098. https://doi.org/10.3390/ijms222212098
Chicago/Turabian StyleHudson, Jaylen, and Laszlo Farkas. 2021. "Epigenetic Regulation of Endothelial Dysfunction and Inflammation in Pulmonary Arterial Hypertension" International Journal of Molecular Sciences 22, no. 22: 12098. https://doi.org/10.3390/ijms222212098