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Article

PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding

A.M. Butlerov’ Chemistry Institute, Kazan Federal University, 420008 Kazan, Russia
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Academic Editors: John G. Hardy and Emily R. Draper
Int. J. Mol. Sci. 2021, 22(21), 11901; https://doi.org/10.3390/ijms222111901
Received: 18 October 2021 / Revised: 29 October 2021 / Accepted: 30 October 2021 / Published: 2 November 2021
(This article belongs to the Special Issue Supramolecular Materials)
A convenient method for the synthesis of the first generation PAMAM dendrimers based on the thiacalix[4]arene has been developed for the first time. Three new PAMAM-calix-dendrimers with the macrocyclic core in cone, partial cone, and 1,3-alternate conformations were obtained with high yields. The interaction of the obtained compounds with salmon sperm DNA resulted in the formation of the associates of the size up to 200 nm, as shown by the UV-Vis spectroscopy, DLS, and TEM. It was demonstrated by the CD method that the structure of the DNA did not undergo significant changes upon binding. The PAMAM-calix-dendrimer based on the macrocycle in cone conformation stabilized DNA and prevented its degradation. View Full-Text
Keywords: thiacalixarene; DNA; dendrimer; PAMAM; DNA binding; DNA storage thiacalixarene; DNA; dendrimer; PAMAM; DNA binding; DNA storage
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MDPI and ACS Style

Mostovaya, O.; Padnya, P.; Shiabiev, I.; Mukhametzyanov, T.; Stoikov, I. PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding. Int. J. Mol. Sci. 2021, 22, 11901. https://doi.org/10.3390/ijms222111901

AMA Style

Mostovaya O, Padnya P, Shiabiev I, Mukhametzyanov T, Stoikov I. PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding. International Journal of Molecular Sciences. 2021; 22(21):11901. https://doi.org/10.3390/ijms222111901

Chicago/Turabian Style

Mostovaya, Olga, Pavel Padnya, Igor Shiabiev, Timur Mukhametzyanov, and Ivan Stoikov. 2021. "PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding" International Journal of Molecular Sciences 22, no. 21: 11901. https://doi.org/10.3390/ijms222111901

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