Towards the Idea of Molecular Brains
Abstract
Undoubtedly, only artists devote themselves to science…(Santiago Ramon y Cajal)
1. Introduction
1.1. Feeding Without Feedback: Chaplin and the “Machine Metaphor” of Life
1.2. Information Transfer, Processing and Behaviours at the Molecular Scale
1.3. The Roots of the Molecular Brain Metaphor
1.4. Brains Beyond Connectomes
1.5. Where the “Molecular Brains” Could Take Us?
2. The Psychic Life of Microorganisms
2.1. Cajal and the Neuronal Turn of the Neurosciences
2.2. Binet, Jennings and Gelber: Toward Neuron-Free Neurosciences?
2.3. Finally, What Is Behaviour?
2.4. Categories of Molecular and Cellular Behaviours: From Sensorimotor Control to Decision Making
2.5. Cell Cognition and Consciousness
3. Cell Signalling and Sensory Motricity
3.1. The “Sensitive” Nature of Biological Molecules
3.2. Gated Channels
3.2.1. Voltage-Gated Channels
3.2.2. Temperature-Gated Channel
3.2.3. Mechanosensitive Ion Channels
3.2.4. Light-Sensitive Channels
3.2.5. Ligand-Gated Channels
3.3. Membrane Receptors
3.3.1. G Protein-Coupled Receptors (GPCR)
3.3.2. Kinases and Protein Phosphorylation
3.3.3. Photoreceptors
3.4. Other Molecular Sensors
3.4.1. Magnetoreception
3.4.2. Stress and Stressosome
3.4.3. Sensing with Nucleic Acids
3.5. The First Proto-Brains’ Ideas in Bacterial Chemotaxis
4. Ribosome Signalling and Primordial Molecular Brains
5. Evolution of Informational Systems across Scales
5.1. Comparison of Signalling Systems
5.2. Bayesian Brain Hypothesis
5.3. Beyond Allostery? Aromaticity in Signal Integration and Decision Making
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Timsit, Y.; Grégoire, S.-P. Towards the Idea of Molecular Brains. Int. J. Mol. Sci. 2021, 22, 11868. https://doi.org/10.3390/ijms222111868
Timsit Y, Grégoire S-P. Towards the Idea of Molecular Brains. International Journal of Molecular Sciences. 2021; 22(21):11868. https://doi.org/10.3390/ijms222111868
Chicago/Turabian StyleTimsit, Youri, and Sergeant-Perthuis Grégoire. 2021. "Towards the Idea of Molecular Brains" International Journal of Molecular Sciences 22, no. 21: 11868. https://doi.org/10.3390/ijms222111868
APA StyleTimsit, Y., & Grégoire, S.-P. (2021). Towards the Idea of Molecular Brains. International Journal of Molecular Sciences, 22(21), 11868. https://doi.org/10.3390/ijms222111868