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Article

Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice

by
Shun-Hua Chen
1,
Yu-Jheng Lin
1,
Li-Chiu Wang
2,
Hsien-Yang Tsai
3,
Chang-Hao Yang
4,
Yu-Ti Teng
5 and
Sheng-Min Hsu
5,*
1
Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
2
School of Medicine, I-Shou University, Kaohsiung 824, Taiwan
3
Department of Ophthalmology, Tzu Chi Hospital, Taichung 427, Taiwan
4
Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan
5
Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(21), 11670; https://doi.org/10.3390/ijms222111670
Submission received: 28 September 2021 / Revised: 22 October 2021 / Accepted: 25 October 2021 / Published: 28 October 2021
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

After successful surgeries for patients with rhegmatogenous retinal detachment, the most common cause of retinal redetachment is proliferative vitreoretinopathy (PVR), which causes severe vision impairment and even blindness worldwide. Until now, the major treatment for PVR is surgical removal of the epiretinal membrane, while effective treatment to prevent PVR is still unavailable. Therefore, we investigated the potential of doxycycline, an antibiotic in the tetracycline class, to treat PVR using a mouse model. We used the human retinal pigment epithelial cell line, ARPE-19, for in vitro and in vivo studies to test doxycycline for PVR treatment. We found that doxycycline suppressed the migration, proliferation, and contraction of ARPE-19 cells with reduced p38 MAPK activation and total MMP activity. Intravitreal doxycycline and topical tetracycline treatment significantly ameliorated the PVR severity induced by ARPE-19 cells in mice. PVR increased the expression of MMP-9 and IL-4 and p38 MAPK phosphorylation and modestly decreased IL-10. These effects were reversed by doxycycline and tetracycline treatment in the mouse retina. These results suggest that doxycycline will be a potential treatment for PVR in the future.
Keywords: doxycycline; proliferative vitreoretinopathy (PVR); rhegmatogenous retinal detachment (RRD) doxycycline; proliferative vitreoretinopathy (PVR); rhegmatogenous retinal detachment (RRD)

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MDPI and ACS Style

Chen, S.-H.; Lin, Y.-J.; Wang, L.-C.; Tsai, H.-Y.; Yang, C.-H.; Teng, Y.-T.; Hsu, S.-M. Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice. Int. J. Mol. Sci. 2021, 22, 11670. https://doi.org/10.3390/ijms222111670

AMA Style

Chen S-H, Lin Y-J, Wang L-C, Tsai H-Y, Yang C-H, Teng Y-T, Hsu S-M. Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice. International Journal of Molecular Sciences. 2021; 22(21):11670. https://doi.org/10.3390/ijms222111670

Chicago/Turabian Style

Chen, Shun-Hua, Yu-Jheng Lin, Li-Chiu Wang, Hsien-Yang Tsai, Chang-Hao Yang, Yu-Ti Teng, and Sheng-Min Hsu. 2021. "Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice" International Journal of Molecular Sciences 22, no. 21: 11670. https://doi.org/10.3390/ijms222111670

APA Style

Chen, S.-H., Lin, Y.-J., Wang, L.-C., Tsai, H.-Y., Yang, C.-H., Teng, Y.-T., & Hsu, S.-M. (2021). Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice. International Journal of Molecular Sciences, 22(21), 11670. https://doi.org/10.3390/ijms222111670

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