From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release

Egle, Karina; Salma, Ilze; Dubnika, Arita

doi:10.3390/ijms222111553

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From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release

Karina Egle

^1,2,

Ilze Salma

^2,3 and

Arita Dubnika

^1,2,*

Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering, Riga Technical University, LV-1658 Riga, Latvia

Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1658 Riga, Latvia

Institute of Stomatology, Rīga Stradiņš University, LV-1007 Riga, Latvia

Author to whom correspondence should be addressed.

Academic Editors: Tomoyuki Kawase and Monica Montesi

Int. J. Mol. Sci. 2021, 22(21), 11553; https://doi.org/10.3390/ijms222111553

Received: 6 September 2021 / Revised: 18 October 2021 / Accepted: 18 October 2021 / Published: 26 October 2021

(This article belongs to the Special Issue Regenerative Therapy Using Blood-Derived Biomaterials)

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Abstract

The purpose of this review is to examine the latest literature on the use of autologous platelet-rich fibrin as a drug and growth factor carrier system in maxillofacial surgery. Autologous platelet-rich fibrin (PRF) is a unique system that combines properties such as biocompatibility and biodegradability, in addition to containing growth factors and peptides that provide tissue regeneration. This opens up new horizons for the use of all beneficial ingredients in the blood sample for biomedical purposes. By itself, PRF has an unstable effect on osteogenesis: therefore, advanced approaches, including the combination of PRF with materials or drugs, are of great interest in clinics. The main advantage of drug delivery systems is that by controlling drug release, high drug concentrations locally and fewer side effects within other tissue can be achieved. This is especially important in tissues with limited blood supply, such as bone tissue compared to soft tissue. The ability of PRF to degrade naturally is considered an advantage for its use as a “warehouse” of controlled drug release systems. We are focusing on this concentrate, as it is easy to use in manipulations and can be delivered directly to the surgical site. The target audience for this review are researchers and medical doctors who are involved in the development and research of PRFs further studies. Likewise, surgeons who use PRF in their work to treat patients and who advice patients to take the medicine orally. View Full-Text

Keywords: platelet-rich fibrin; endogenous growth factors; carrier systems; drug delivery; platelet concentrates; tissue engineering; autologous growth factors

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Egle, K.; Salma, I.; Dubnika, A. From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release. Int. J. Mol. Sci. 2021, 22, 11553. https://doi.org/10.3390/ijms222111553

AMA Style

Egle K, Salma I, Dubnika A. From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release. International Journal of Molecular Sciences. 2021; 22(21):11553. https://doi.org/10.3390/ijms222111553

Chicago/Turabian Style

Egle, Karina, Ilze Salma, and Arita Dubnika. 2021. "From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release" International Journal of Molecular Sciences 22, no. 21: 11553. https://doi.org/10.3390/ijms222111553

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From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release

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