Next Article in Journal
Characterization of Pathogenicity-Associated V2 Protein of Tobacco Curly Shoot Virus
Next Article in Special Issue
CNBP Binds and Unfolds In Vitro G-Quadruplexes Formed in the SARS-CoV-2 Positive and Negative Genome Strands
Previous Article in Journal
Quantitative Proteomics Reveals that GmENO2 Proteins Are Involved in Response to Phosphate Starvation in the Leaves of Glycine max L.
Review

Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins

Department of Biology and Ecology, Institute of Environmental Technologies, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 922; https://doi.org/10.3390/ijms22020922
Received: 29 December 2020 / Revised: 15 January 2021 / Accepted: 16 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Impacts of Molecular Structure on Nucleic Acid–Protein Interactions)
Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category. View Full-Text
Keywords: DNA; RNA; protein binding; G-quadruplex; triplex; i-motif; Z-DNA; Z-RNA; cruciform; amino acid composition DNA; RNA; protein binding; G-quadruplex; triplex; i-motif; Z-DNA; Z-RNA; cruciform; amino acid composition
Show Figures

Figure 1

MDPI and ACS Style

Bartas, M.; Červeň, J.; Guziurová, S.; Slychko, K.; Pečinka, P. Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins. Int. J. Mol. Sci. 2021, 22, 922. https://doi.org/10.3390/ijms22020922

AMA Style

Bartas M, Červeň J, Guziurová S, Slychko K, Pečinka P. Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins. International Journal of Molecular Sciences. 2021; 22(2):922. https://doi.org/10.3390/ijms22020922

Chicago/Turabian Style

Bartas, Martin, Jiří Červeň, Simona Guziurová, Kristyna Slychko, and Petr Pečinka. 2021. "Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins" International Journal of Molecular Sciences 22, no. 2: 922. https://doi.org/10.3390/ijms22020922

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop