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Characterization of a Topically Testable Model of Burn Injury on Human Skin Explants
Review

Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation)

1
Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia
2
Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia
3
Department of Pathology, Louise Pasteur University Hospital, 041 90 Košice, Slovakia
4
Center of Clinical and Preclinical Research MediPark, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia
5
Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, 100 34 Prague, Czech Republic
6
Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic
7
BIOCEV, 252 50 Vestec, Czech Republic
8
Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 897; https://doi.org/10.3390/ijms22020897
Received: 8 January 2021 / Revised: 13 January 2021 / Accepted: 14 January 2021 / Published: 18 January 2021
Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation. View Full-Text
Keywords: wound healing; skin; burn; pathological scar; cell interaction; stem cell wound healing; skin; burn; pathological scar; cell interaction; stem cell
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MDPI and ACS Style

Čoma, M.; Fröhlichová, L.; Urban, L.; Zajíček, R.; Urban, T.; Szabo, P.; Novák, Š.; Fetissov, V.; Dvořánková, B.; Smetana, K., Jr.; Gál, P. Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation). Int. J. Mol. Sci. 2021, 22, 897. https://doi.org/10.3390/ijms22020897

AMA Style

Čoma M, Fröhlichová L, Urban L, Zajíček R, Urban T, Szabo P, Novák Š, Fetissov V, Dvořánková B, Smetana K Jr., Gál P. Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation). International Journal of Molecular Sciences. 2021; 22(2):897. https://doi.org/10.3390/ijms22020897

Chicago/Turabian Style

Čoma, Matúš, Lucia Fröhlichová, Lukáš Urban, Robert Zajíček, Tomáš Urban, Pavol Szabo, Štěpán Novák, Vitaly Fetissov, Barbora Dvořánková, Karel Smetana Jr., and Peter Gál. 2021. "Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation)" International Journal of Molecular Sciences 22, no. 2: 897. https://doi.org/10.3390/ijms22020897

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