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The Roles of Sodium-Independent Inorganic Phosphate Transporters in Inorganic Phosphate Homeostasis and in Cancer and Other Diseases

Modulation of Intestinal Phosphate Transport in Young Goats Fed a Low Phosphorus Diet

Institute for Physiology and Cell Biology, University of Veterinary Medicine Hannover, 30173 Hannover, Germany
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 866;
Received: 19 December 2020 / Revised: 7 January 2021 / Accepted: 13 January 2021 / Published: 16 January 2021
(This article belongs to the Special Issue Mechanisms of Phosphate Transport)
The intestinal absorption of phosphate (Pi) takes place transcellularly through the active NaPi-cotransporters type IIb (NaPiIIb) and III (PiT1 and PiT2) and paracellularly by diffusion through tight junction (TJ) proteins. The localisation along the intestines and the regulation of Pi absorption differ between species and are not fully understood. It is known that 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D3) and phosphorus (P) depletion modulate intestinal Pi absorption in vertebrates in different ways. In addition to the apical uptake into the enterocytes, there are uncertainties regarding the basolateral excretion of Pi. Functional ex vivo experiments in Ussing chambers and molecular studies of small intestinal epithelia were carried out on P-deficient goats in order to elucidate the transepithelial Pi route in the intestine as well as the underlying mechanisms of its regulation and the proteins, which may be involved. The dietary P reduction had no effect on the duodenal and ileal Pi transport rate in growing goats. The ileal PiT1 and PiT2 mRNA expressions increased significantly, while the ileal PiT1 protein expression, the mid jejunal claudin-2 mRNA expression and the serum 1,25-(OH)2D3 levels were significantly reduced. These results advance the state of knowledge concerning the complex mechanisms of the Pi homeostasis in vertebrates. View Full-Text
Keywords: intestine; NaPiIIb; phosphate homeostasis; PiT1; PiT2 intestine; NaPiIIb; phosphate homeostasis; PiT1; PiT2
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MDPI and ACS Style

Behrens, J.L.; Schnepel, N.; Hansen, K.; Hustedt, K.; Burmester, M.; Klinger, S.; Breves, G.; Muscher-Banse, A.S. Modulation of Intestinal Phosphate Transport in Young Goats Fed a Low Phosphorus Diet. Int. J. Mol. Sci. 2021, 22, 866.

AMA Style

Behrens JL, Schnepel N, Hansen K, Hustedt K, Burmester M, Klinger S, Breves G, Muscher-Banse AS. Modulation of Intestinal Phosphate Transport in Young Goats Fed a Low Phosphorus Diet. International Journal of Molecular Sciences. 2021; 22(2):866.

Chicago/Turabian Style

Behrens, Joie L., Nadine Schnepel, Kathrin Hansen, Karin Hustedt, Marion Burmester, Stefanie Klinger, Gerhard Breves, and Alexandra S. Muscher-Banse 2021. "Modulation of Intestinal Phosphate Transport in Young Goats Fed a Low Phosphorus Diet" International Journal of Molecular Sciences 22, no. 2: 866.

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