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Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

1
Department of Agricultural, Food and Forest Sciences, University of Palermo, Viale delle Scienze, Bldg. 5, I-90128 Palermo, Italy
2
Department of Agricultural and Environmental Science, University of Bari Aldo Moro, Via Amendola 165/A, I-70126 Bari, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 634; https://doi.org/10.3390/ijms22020634
Received: 28 December 2020 / Revised: 4 January 2021 / Accepted: 7 January 2021 / Published: 10 January 2021
(This article belongs to the Special Issue Biological Properties of Secondary Metabolites and Natural Compounds)
Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical studies are reported in this review. Besides, we analyzed the therapeutic use and pharmacological activities of mushrooms. View Full-Text
Keywords: medicinal mushrooms; pharmaceutical properties; biomolecules; immunomodulation; antitumor property; dietary supplements; in vitro study; clinical trial; mycotherapy medicinal mushrooms; pharmaceutical properties; biomolecules; immunomodulation; antitumor property; dietary supplements; in vitro study; clinical trial; mycotherapy
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MDPI and ACS Style

Venturella, G.; Ferraro, V.; Cirlincione, F.; Gargano, M.L. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int. J. Mol. Sci. 2021, 22, 634. https://doi.org/10.3390/ijms22020634

AMA Style

Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. International Journal of Molecular Sciences. 2021; 22(2):634. https://doi.org/10.3390/ijms22020634

Chicago/Turabian Style

Venturella, Giuseppe, Valeria Ferraro, Fortunato Cirlincione, and Maria L. Gargano 2021. "Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials" International Journal of Molecular Sciences 22, no. 2: 634. https://doi.org/10.3390/ijms22020634

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