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Zebrafish, Medaka and Turquoise Killifish for Understanding Human Neurodegenerative/Neurodevelopmental Disorders
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Efficient Neuroprotective Rescue of Sacsin-Related Disease Phenotypes in Zebrafish

Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases

by 1,2 and 1,2,*
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7#, Wuhan 430072, China
College of Advanced Agriculture Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Author to whom correspondence should be addressed.
Academic Editor: Masashi Tanaka
Int. J. Mol. Sci. 2021, 22(19), 10766;
Received: 27 July 2021 / Revised: 30 September 2021 / Accepted: 30 September 2021 / Published: 5 October 2021
(This article belongs to the Special Issue Molecular Pathogenesis of Neurodegeneration: From Fish to Human)
Animal models of human neurodegenerative disease have been investigated for several decades. In recent years, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become popular in pathogenic and therapeutic studies about human neurodegenerative diseases due to their small size, the optical clarity of embryos, their fast development, and their suitability to large-scale therapeutic screening. Following the emergence of a new generation of molecular biological technologies such as reverse and forward genetics, morpholino, transgenesis, and gene knockout, many human neurodegenerative disease models, such as Parkinson’s, Huntington’s, and Alzheimer’s, were constructed in zebrafish and medaka. These studies proved that zebrafish and medaka genes are functionally conserved in relation to their human homologues, so they exhibit similar neurodegenerative phenotypes to human beings. Therefore, fish are a suitable model for the investigation of pathologic mechanisms of neurodegenerative diseases and for the large-scale screening of drugs for potential therapy. In this review, we summarize the studies in modelling human neurodegenerative diseases in zebrafish and medaka in recent years. View Full-Text
Keywords: zebrafish; medaka; disease models; neurodegenerative zebrafish; medaka; disease models; neurodegenerative
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MDPI and ACS Style

Wang, J.; Cao, H. Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases. Int. J. Mol. Sci. 2021, 22, 10766.

AMA Style

Wang J, Cao H. Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases. International Journal of Molecular Sciences. 2021; 22(19):10766.

Chicago/Turabian Style

Wang, Jing, and Hong Cao. 2021. "Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases" International Journal of Molecular Sciences 22, no. 19: 10766.

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