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Article

Plasmidome of Listeria spp.—The repA-Family Business

1
Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland
2
Department of Molecular Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland
3
Department of Environmental Microbiology and Biotechnology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Academic Editors: Vicky Merhej and Pierre Pontarotti
Int. J. Mol. Sci. 2021, 22(19), 10320; https://doi.org/10.3390/ijms221910320
Received: 30 August 2021 / Revised: 22 September 2021 / Accepted: 22 September 2021 / Published: 25 September 2021
(This article belongs to the Special Issue Microbial Comparative Genomics and Evolutionary Biology)
Bacteria of the genus Listeria (phylum Firmicutes) include both human and animal pathogens, as well as saprophytic strains. A common component of Listeria spp. genomes are plasmids, i.e., extrachromosomal replicons that contribute to gene flux in bacteria. This study provides an in-depth insight into the structure, diversity and evolution of plasmids occurring in Listeria strains inhabiting various environments under different anthropogenic pressures. Apart from the components of the conserved plasmid backbone (providing replication, stable maintenance and conjugational transfer functions), these replicons contain numerous adaptive genes possibly involved in: (i) resistance to antibiotics, heavy metals, metalloids and sanitizers, and (ii) responses to heat, oxidative, acid and high salinity stressors. Their genomes are also enriched by numerous transposable elements, which have influenced the plasmid architecture. The plasmidome of Listeria is dominated by a group of related replicons encoding the RepA replication initiation protein. Detailed comparative analyses provide valuable data on the level of conservation of these replicons and their role in shaping the structure of the Listeria pangenome, as well as their relationship to plasmids of other genera of Firmicutes, which demonstrates the range and direction of flow of genetic information in this important group of bacteria. View Full-Text
Keywords: Listeria; plasmids; adaptation; heavy metal resistance; plasmidome; pangenome; Firmicutes; horizontal gene transfer Listeria; plasmids; adaptation; heavy metal resistance; plasmidome; pangenome; Firmicutes; horizontal gene transfer
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MDPI and ACS Style

Chmielowska, C.; Korsak, D.; Chapkauskaitse, E.; Decewicz, P.; Lasek, R.; Szuplewska, M.; Bartosik, D. Plasmidome of Listeria spp.—The repA-Family Business. Int. J. Mol. Sci. 2021, 22, 10320. https://doi.org/10.3390/ijms221910320

AMA Style

Chmielowska C, Korsak D, Chapkauskaitse E, Decewicz P, Lasek R, Szuplewska M, Bartosik D. Plasmidome of Listeria spp.—The repA-Family Business. International Journal of Molecular Sciences. 2021; 22(19):10320. https://doi.org/10.3390/ijms221910320

Chicago/Turabian Style

Chmielowska, Cora, Dorota Korsak, Elvira Chapkauskaitse, Przemysław Decewicz, Robert Lasek, Magdalena Szuplewska, and Dariusz Bartosik. 2021. "Plasmidome of Listeria spp.—The repA-Family Business" International Journal of Molecular Sciences 22, no. 19: 10320. https://doi.org/10.3390/ijms221910320

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