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The Dynamic Network of RNP RNase P Subunits

Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece
Author to whom correspondence should be addressed.
Authors with equal contribution.
Academic Editors: Ian A. Nicholls, Vladimir N. Uversky and Victor Muñoz
Int. J. Mol. Sci. 2021, 22(19), 10307;
Received: 6 September 2021 / Revised: 22 September 2021 / Accepted: 23 September 2021 / Published: 24 September 2021
(This article belongs to the Special Issue Regulation by Non-coding RNAs 2022)
Ribonuclease P (RNase P) is an important ribonucleoprotein (RNP), responsible for the maturation of the 5′ end of precursor tRNAs (pre-tRNAs). In all organisms, the cleavage activity of a single phosphodiester bond adjacent to the first nucleotide of the acceptor stem is indispensable for cell viability and lies within an essential catalytic RNA subunit. Although RNase P is a ribozyme, its kinetic efficiency in vivo, as well as its structural variability and complexity throughout evolution, requires the presence of one protein subunit in bacteria to several protein partners in archaea and eukaryotes. Moreover, the existence of protein-only RNase P (PRORP) enzymes in several organisms and organelles suggests a more complex evolutionary timeline than previously thought. Recent detailed structures of bacterial, archaeal, human and mitochondrial RNase P complexes suggest that, although apparently dissimilar enzymes, they all recognize pre-tRNAs through conserved interactions. Interestingly, individual protein subunits of the human nuclear and mitochondrial holoenzymes have additional functions and contribute to a dynamic network of elaborate interactions and cellular processes. Herein, we summarize the role of each RNase P subunit with a focus on the human nuclear RNP and its putative role in flawless gene expression in light of recent structural studies. View Full-Text
Keywords: RNase P; pre-tRNA; RNPs; Rpps; ribozyme RNase P; pre-tRNA; RNPs; Rpps; ribozyme
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MDPI and ACS Style

Shaukat, A.-N.; Kaliatsi, E.G.; Skeparnias, I.; Stathopoulos, C. The Dynamic Network of RNP RNase P Subunits. Int. J. Mol. Sci. 2021, 22, 10307.

AMA Style

Shaukat A-N, Kaliatsi EG, Skeparnias I, Stathopoulos C. The Dynamic Network of RNP RNase P Subunits. International Journal of Molecular Sciences. 2021; 22(19):10307.

Chicago/Turabian Style

Shaukat, Athanasios-Nasir, Eleni G. Kaliatsi, Ilias Skeparnias, and Constantinos Stathopoulos. 2021. "The Dynamic Network of RNP RNase P Subunits" International Journal of Molecular Sciences 22, no. 19: 10307.

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