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RNA Granules in the Mitochondria and Their Organization under Mitochondrial Stresses

Department of Cell Biology, Faculty of Sciences, University of Geneva, 1205 Geneva, Switzerland
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Author to whom correspondence should be addressed.
Academic Editors: María Eugenia Soriano and Carlo Viscomi
Int. J. Mol. Sci. 2021, 22(17), 9502; https://doi.org/10.3390/ijms22179502
Received: 5 August 2021 / Revised: 25 August 2021 / Accepted: 27 August 2021 / Published: 1 September 2021
(This article belongs to the Special Issue Molecular Research on Mitochondrial Dysfunction)
The human mitochondrial genome (mtDNA) regulates its transcription products in specialised and distinct ways as compared to nuclear transcription. Thanks to its mtDNA mitochondria possess their own set of tRNAs, rRNAs and mRNAs that encode a subset of the protein subunits of the electron transport chain complexes. The RNA regulation within mitochondria is organised within specialised, membraneless, compartments of RNA-protein complexes, called the Mitochondrial RNA Granules (MRGs). MRGs were first identified to contain nascent mRNA, complexed with many proteins involved in RNA processing and maturation and ribosome assembly. Most recently, double-stranded RNA (dsRNA) species, a hybrid of the two complementary mRNA strands, were found to form granules in the matrix of mitochondria. These RNA granules are therefore components of the mitochondrial post-transcriptional pathway and as such play an essential role in mitochondrial gene expression. Mitochondrial dysfunctions in the form of, for example, RNA processing or RNA quality control defects, or inhibition of mitochondrial fission, can cause the loss or the aberrant accumulation of these RNA granules. These findings underline the important link between mitochondrial maintenance and the efficient expression of its genome. View Full-Text
Keywords: mitochondrial RNA granules (MRGs); dsRNA; degradosome; nucleoids; mitochondrial gene expression; RNA processing; RNA degradation; liquid–liquid phase separation (LLPS) mitochondrial RNA granules (MRGs); dsRNA; degradosome; nucleoids; mitochondrial gene expression; RNA processing; RNA degradation; liquid–liquid phase separation (LLPS)
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MDPI and ACS Style

Xavier, V.J.; Martinou, J.-C. RNA Granules in the Mitochondria and Their Organization under Mitochondrial Stresses. Int. J. Mol. Sci. 2021, 22, 9502. https://doi.org/10.3390/ijms22179502

AMA Style

Xavier VJ, Martinou J-C. RNA Granules in the Mitochondria and Their Organization under Mitochondrial Stresses. International Journal of Molecular Sciences. 2021; 22(17):9502. https://doi.org/10.3390/ijms22179502

Chicago/Turabian Style

Xavier, Vanessa J., and Jean-Claude Martinou. 2021. "RNA Granules in the Mitochondria and Their Organization under Mitochondrial Stresses" International Journal of Molecular Sciences 22, no. 17: 9502. https://doi.org/10.3390/ijms22179502

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