Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Articles Selection
3.2. TCDD Transgenerational Effects on Female Reproductive Health
3.3. TCDD Transgenerational Effects on Male Reproduction
3.4. Transgenerational Epigenetic Mechanisms
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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F3 Females | Paternal Germline | Paternal and Maternal Germline | Maternal Germline |
---|---|---|---|
Fertility | ↓ [57] 2 | ||
Ovarian weight | N [54] 1 | ↓ [58] 3 | |
Ovarian primordial follicles | ↓ [55] 1 | ↓ [58] 3 | |
Granulosa cell apoptosis around growing follicles | ↑ [59] 3 | ||
AMH concentration | N [59] 3 | ||
Earlier pubertal maturation | ↑ [54,56] 1 | ↑ [58] 3 | |
Estrous cycle abnormalities | ↑ [58] 3 | ||
Polycystic ovaries | ↑ [54] 1 | ||
Adenomyosis | ↑ [60] 2 | ||
F3 Males | Paternal Germline | Paternal and Maternal Germline | Maternal Germline |
Fertility | ↓ [61] 2 | ||
Testosterone concentration | ↓ (ns) [61] 2 ↓ (ns) [62] 4 | ↓ [56] 1 | |
LH concentration | N [61] 2 N [62] 4 | N [56] 1 | |
Sperm number | N [61] 2 | ||
Normal sperm morphology | ↓ [61] 2 N [62] 4 | ||
Epididymal sperm concentration and motility | N [62] 4 | N [56] 1 | |
Epididymis and prostate weight | N [54] 1 | ||
Testis and prostate diseases/abnormalities | N [54] 1 | ||
Pubertal development | N [54] 1 | ||
F3 Pregnancies | Paternal Germline | Paternal and Maternal Germline | Maternal Germline |
Premature birth | ↑ [61] 2 | ↑ [57] 2 | |
Litter size at birth | ↓ [63] 6 N [54] 1 | ||
Number of implanted embryos and number of implanted embryos per corpus luteum | ↓ [62] 4 | ||
Placental weight | ↓ [64] 5 | ||
Pup weight | ↓ [64] 5 | ||
Gestation survival index | ↓ [63] 6 | ||
Male/female sex ratio | N [65] 6 N [54] 1 | ||
Ascending GBS infection during pregnancy | Maternal health and gestation length N, neonatal survival ↓ [66] 5 | 100% maternal and fetal mortality [66] 5 | |
Infertility and premature birth after latent MPV | ↑ [57] 2 |
F3 Females | Paternal Germline | Paternal and Maternal Germline | Maternal Germline |
---|---|---|---|
AMH mRNA ↓ and AMHR2 mRNA ↑ in the ovary [58] 1 | |||
Igf2 mRNA ↓ and H19 mRNA ↑ in the ovary [66] 1 | |||
F3 Males | Paternal Germline | Paternal and Maternal Germline | Maternal Germline |
DMR epimutations in testes [67] 2 | DMR epimutations in sperm [54] 4 | ||
DMR epimutations in sperm [64] 3 | Disease-specific DMR epimutations in sperm [10] 4 | ||
DMR epimutations in male-derived placentae [64] 3 | |||
Pgr, Igf2 and H19 mRNA ↓ in male-derived placentae [64] 3 |
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Gaspari, L.; Paris, F.; Kalfa, N.; Soyer-Gobillard, M.-O.; Sultan, C.; Hamamah, S. Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health. Int. J. Mol. Sci. 2021, 22, 9091. https://doi.org/10.3390/ijms22169091
Gaspari L, Paris F, Kalfa N, Soyer-Gobillard M-O, Sultan C, Hamamah S. Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health. International Journal of Molecular Sciences. 2021; 22(16):9091. https://doi.org/10.3390/ijms22169091
Chicago/Turabian StyleGaspari, Laura, Françoise Paris, Nicolas Kalfa, Marie-Odile Soyer-Gobillard, Charles Sultan, and Samir Hamamah. 2021. "Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive Health" International Journal of Molecular Sciences 22, no. 16: 9091. https://doi.org/10.3390/ijms22169091