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Chronic Low Dose Neutron Exposure Results in Altered Neurotransmission Properties of the Hippocampus-Prefrontal Cortex Axis in Both Mice and Rats
Article

Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function

1
Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA
2
Department of Radiation Oncology, University of California, Irvine, CA 92697, USA
3
Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Melpo Christofidou-Solomidou and Thomas J. Goodwin
Int. J. Mol. Sci. 2021, 22(16), 9020; https://doi.org/10.3390/ijms22169020
Received: 17 July 2021 / Revised: 17 August 2021 / Accepted: 19 August 2021 / Published: 21 August 2021
A recognized risk of long-duration space travel arises from the elevated exposure astronauts face from galactic cosmic radiation (GCR), which is composed of a diverse array of energetic particles. There is now abundant evidence that exposures to many different charged particle GCR components within acute time frames are sufficient to induce central nervous system deficits that span from the molecular to the whole animal behavioral scale. Enhanced spacecraft shielding can lessen exposures to charged particle GCR components, but may conversely elevate neutron radiation levels. We previously observed that space-relevant neutron radiation doses, chronically delivered at dose-rates expected during planned human exploratory missions, can disrupt hippocampal neuronal excitability, perturb network long-term potentiation and negatively impact cognitive behavior. We have now determined that acute exposures to similar low doses (18 cGy) of neutron radiation can also lead to suppressed hippocampal synaptic signaling, as well as decreased learning and memory performance in male mice. Our results demonstrate that similar nervous system hazards arise from neutron irradiation regardless of the exposure time course. While not always in an identical manner, neutron irradiation disrupts many of the same central nervous system elements as acute charged particle GCR exposures. The risks arising from neutron irradiation are therefore important to consider when determining the overall hazards astronauts will face from the space radiation environment. View Full-Text
Keywords: cognitive dysfunction; electrophysiology; long-term potentiation; neutrons; space radiation cognitive dysfunction; electrophysiology; long-term potentiation; neutrons; space radiation
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MDPI and ACS Style

Klein, P.M.; Alaghband, Y.; Doan, N.-L.; Ru, N.; Drayson, O.G.G.; Baulch, J.E.; Kramár, E.A.; Wood, M.A.; Soltesz, I.; Limoli, C.L. Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function. Int. J. Mol. Sci. 2021, 22, 9020. https://doi.org/10.3390/ijms22169020

AMA Style

Klein PM, Alaghband Y, Doan N-L, Ru N, Drayson OGG, Baulch JE, Kramár EA, Wood MA, Soltesz I, Limoli CL. Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function. International Journal of Molecular Sciences. 2021; 22(16):9020. https://doi.org/10.3390/ijms22169020

Chicago/Turabian Style

Klein, Peter M., Yasaman Alaghband, Ngoc-Lien Doan, Ning Ru, Olivia G.G. Drayson, Janet E. Baulch, Enikö A. Kramár, Marcelo A. Wood, Ivan Soltesz, and Charles L. Limoli 2021. "Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function" International Journal of Molecular Sciences 22, no. 16: 9020. https://doi.org/10.3390/ijms22169020

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