Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer
Abstract
:1. Introduction
2. Results
2.1. Determination of the Heating Power Necessary for MNPs in the Presence of Blood Flow and Metabolism to Effectively Damage the Tumor Tissues
2.2. Determination of Optimized Pulsed Powers for Various Source Diameters to Get High Fraction of Tumor Damage
3. Discussion
4. Material and Methods
4.1. Breast Cancer Model and Bio-Heat Transfer Model
4.2. Fourier’s Law for Estimating Heating Power Necessary for Magnetic Nanoparticles
4.3. Arrhenius Equation for Fraction of Tissue Damage
4.4. Methods
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Diameter of Source Domain (mm) | P0 (W/m3) to Increase 6 °C at Treated Domain | PMNPs (W/m3) to Reach Fraction of Tumor Damage of at Least 70% |
---|---|---|
1 | 2.30 × 107 | 4.8 × 107 |
2 | 0.57 × 107 | 3.6 × 107 |
3 | 0.25 × 107 | 2.2 × 107 |
4 | 0.14 × 107 | 1.9 × 107 |
5 | 0.92 × 107 | 1.8 × 107 |
6 | 0.64 × 107 | 1.7 × 107 |
Source Diameter (mm) | Pulsed Powers | Fraction of Damage of Pulsed Power | Fraction of Damage of Continuous Power | |
---|---|---|---|---|
Duty | Cycle (second) | |||
1 | 0.8 | 5 | 0.99983 | 0.71695 |
2 | 0.9 | 10 | 0.99627 | 0.9543 |
3 | 0.9 | 90 | 0.93884 | 0.89937 |
4 | 0.9 | 90 | 0.97700 | 0.96749 |
5 | 0.9 | 95 | 0.99130 | 0.99213 |
6 | 0.9 | 95 | 0.99903 | 0.99972 |
Epidermis | Papillary Dermis | Reticular Dermis | Fat | Gland | Muscle | Tumor | Air | |
---|---|---|---|---|---|---|---|---|
Thickness hth (mm) | 0.1 [48] | 0.7 [48] | 0.8 [48] | 5.0 [49] | 43.4 [49] | 15 [49] | 20 | -- |
k (W/(m.K)) | 0.235 [48] | 0.445 [48] | 0.445 [48] | 0.21 [50] | 0.48 [50] | 0.48 [50] | 0.48 [50] | -- |
ρ (kg/m3) | 1200 [48] | 1200 [48] | 1200 [48] | 930 [51] | 1050 [51] | 1100 [51] | 1050 [51] | -- |
c (J/(kg.K)) | 3589 [48] | 3300 [48] | 3300 [48] | 2770 [51] | 3770 [51] | 3800 [48] | 3852 [48] | -- |
Q0 (W/m3) | 0 [48] | 368.1 [48] | 368.1 [48] | 400 [50] | 700 [50] | 700 [50] | 5000 [52] | -- |
ωb (m3/((s.m3)) | 0 [48] | 0.0002 [48] | 0.0013 [48] | 0.0002 [47] | 0.0006 [47] | 0.0009 [47] | 0.012 [47] | -- |
Initial temperature T0 (°C) | 37 | 37 | 37 | 37 | 37 | 37 | 37 | 25 |
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Cao, T.-L.; Le, T.-A.; Hadadian, Y.; Yoon, J. Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer. Int. J. Mol. Sci. 2021, 22, 8895. https://doi.org/10.3390/ijms22168895
Cao T-L, Le T-A, Hadadian Y, Yoon J. Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer. International Journal of Molecular Sciences. 2021; 22(16):8895. https://doi.org/10.3390/ijms22168895
Chicago/Turabian StyleCao, Thanh-Luu, Tuan-Anh Le, Yaser Hadadian, and Jungwon Yoon. 2021. "Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer" International Journal of Molecular Sciences 22, no. 16: 8895. https://doi.org/10.3390/ijms22168895