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Review

What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options

by 1,2,3,4
1
Department of Surgery and Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 4N1, Canada
2
McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, AB T2N 4N1, Canada
3
Alberta Health Services Bone & Joint Health Strategic Clinical Network, Edmonton, AB T5H 3E4, Canada
4
Centre for Hip Health & Mobility, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
Academic Editor: Massimo Conese
Int. J. Mol. Sci. 2021, 22(16), 8637; https://doi.org/10.3390/ijms22168637
Received: 20 July 2021 / Revised: 3 August 2021 / Accepted: 9 August 2021 / Published: 11 August 2021
(This article belongs to the Section Molecular Immunology)
Mesenchymal stem cells, also called medicinal signaling cells (MSC), have been studied regarding their potential to facilitate tissue repair for >30 years. Such cells, derived from multiple tissues and species, are capable of differentiation to a number of lineages (chondrocytes, adipocytes, bone cells). However, MSC are believed to be quite heterogeneous with regard to several characteristics, and the large number of studies performed thus far have met with limited or restricted success. Thus, there is more to understand about these cells, including the molecular recognition systems that are used by these cells to perform their functions, to enhance the realization of their potential to effect tissue repair. This perspective article reviews what is known regarding the recognition systems available to MSC, the possible systems that could be looked for, and alternatives to enhance their localization to specific injury sites and increase their subsequent facilitation of tissue repair. MSC are reported to express recognition molecules of the integrin family. However, there are a number of other recognition molecules that also could be involved such as lectins, inducible lectins, or even a MSC-specific family of molecules unique to these cells. Finally, it may be possible to engineer expression of recognition molecules on the surface of MSC to enhance their function in vivo artificially. Thus, improved understanding of recognition molecules on MSC could further their success in fostering tissue repair. View Full-Text
Keywords: mesenchymal stem cells; medicinal signaling cells; cell surface; recognition systems; cell-cell interactions; cell-matrix interactions mesenchymal stem cells; medicinal signaling cells; cell surface; recognition systems; cell-cell interactions; cell-matrix interactions
MDPI and ACS Style

Hart, D.A. What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options. Int. J. Mol. Sci. 2021, 22, 8637. https://doi.org/10.3390/ijms22168637

AMA Style

Hart DA. What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options. International Journal of Molecular Sciences. 2021; 22(16):8637. https://doi.org/10.3390/ijms22168637

Chicago/Turabian Style

Hart, David A. 2021. "What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options" International Journal of Molecular Sciences 22, no. 16: 8637. https://doi.org/10.3390/ijms22168637

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