Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects
, Celeste Caruso Bavisotto 1,3, Marco De Curtis 4, Rita Garbelli 4, Anna Teresa Giallonardo 5,6, Carlo Di Bonaventura 5,6, Martina Fanella 5,6, Everly Conway de Macario 7, Francesco Cappello 1,3, Alberto J. L. Macario 3,7 and Antonella Marino Gammazza 1,*
Round 1
Reviewer 1 Report
This review is revisiting the latest knowledge about involvement of miRNAs and the chaperone system in epilepsy focusing in particular to temporal lobe epilepsy.
I would advice to check for more recent paper(s) concerned with classifications and characteristic of epilepsy as I suggested on the text.
Then follow few minor comments along the papers.
Comments for author File: 
Comments.pdf
Author Response
We thank Reviewer 1 for the comments and suggestions that we followed in revising the manuscript. Particularly, in the revised version of the manuscript, we added new recent references about classifications and characteristics of epilepsy instead of the previous ones.
Reviewer 2 Report
Manuscript entitled "Molecular chaperones and miRNAs in epilepsy: pathogenic implications and therapeutic prospects"
This review is elegant, informative, and well-structured. It could be acceptable pending minor revisions as followings:
- The authors are encouraged to describe (discuss) the therapeutic relevance.
- A table summarizing key molecules and their roles in epilepsy would be very helpful.
Author Response
We thank Reviewer 2 for the comments and suggestions.
1. We discussed/described the therapeutic relevance in the manuscript: see for example lines 206, 219-225, 356, 374-377, and in the Conclusions and prospects section.
2. In the uploaded revised version of the manuscript we added a table listing the molecular chaperones and miRNAs involved in epileptogenesis and cited in the text, also indicating the molecule state and possible role.
