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Review

Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells

1
Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 08308, Korea
2
Department of Marine Stem Cell and Tissue Engineering, Bushehr University of Medical Sciences, Bushehr 14174, Iran
3
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea
4
Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea
5
Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul 03080, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Anastasios Lymperopoulos
Int. J. Mol. Sci. 2021, 22(16), 8599; https://doi.org/10.3390/ijms22168599
Received: 27 May 2021 / Revised: 5 August 2021 / Accepted: 6 August 2021 / Published: 10 August 2021
With the intent to achieve the best modalities for myocardial cell therapy, different cell types are being evaluated as potent sources for differentiation into cardiomyocytes. Embryonic stem cells and induced pluripotent stem cells have great potential for future progress in the treatment of myocardial diseases. We reviewed aspects of epigenetic mechanisms that play a role in the differentiation of these cells into cardiomyocytes. Cardiomyocytes proliferate during fetal life, and after birth, they undergo permanent terminal differentiation. Upregulation of cardiac-specific genes in adults induces hypertrophy due to terminal differentiation. The repression or expression of these genes is controlled by chromatin structural and epigenetic changes. However, few studies have reviewed and analyzed the epigenetic aspects of the differentiation of embryonic stem cells and induced pluripotent stem cells into cardiac lineage cells. In this review, we focus on the current knowledge of epigenetic regulation of cardiomyocyte proliferation and differentiation from embryonic and induced pluripotent stem cells through histone modification and microRNAs, the maintenance of pluripotency, and its alteration during cardiac lineage differentiation. View Full-Text
Keywords: epigenetic markers; cardiomyocyte; proliferation; differentiation; induced pluripotent stem cell; embryonic stem cell epigenetic markers; cardiomyocyte; proliferation; differentiation; induced pluripotent stem cell; embryonic stem cell
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MDPI and ACS Style

Kim, Y.-J.; Tamadon, A.; Kim, Y.-Y.; Kang, B.-C.; Ku, S.-Y. Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells. Int. J. Mol. Sci. 2021, 22, 8599. https://doi.org/10.3390/ijms22168599

AMA Style

Kim Y-J, Tamadon A, Kim Y-Y, Kang B-C, Ku S-Y. Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells. International Journal of Molecular Sciences. 2021; 22(16):8599. https://doi.org/10.3390/ijms22168599

Chicago/Turabian Style

Kim, Yong-Jin, Amin Tamadon, Yoon-Young Kim, Byeong-Cheol Kang, and Seung-Yup Ku. 2021. "Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells" International Journal of Molecular Sciences 22, no. 16: 8599. https://doi.org/10.3390/ijms22168599

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