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Review

A Review of the Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat Models

1
Department of Animal Sciences, North Carolina Agricultural and Technical State University, 1601 East Market Street, Greensboro, NC 27411, USA
2
Department of Agriculture, University of Arkansas at Pine Bluff, 1200 N. University Drive, Mail Slot 4913, Pine Bluff, AR 71601, USA
3
Research & Economic Development, North Carolina Agricultural and Technical State University, 1601 East Market Street, Greensboro, NC 27411, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Milladur Rahman
Int. J. Mol. Sci. 2021, 22(15), 8046; https://doi.org/10.3390/ijms22158046
Received: 4 May 2021 / Revised: 28 June 2021 / Accepted: 1 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue Molecular Research on Neutrophil Extracellular Trap (NET))
This review provides insight into the importance of understanding NETosis in cows, sheep, and goats in light of the importance to their health, welfare and use as animal models. Neutrophils are essential to innate immunity, pathogen infection, and inflammatory diseases. The relevance of NETosis as a conserved innate immune response mechanism and the translational implications for public health are presented. Increased understanding of NETosis in ruminants will contribute to the prediction of pathologies and design of strategic interventions targeting NETs. This will help to control pathogens such as coronaviruses and inflammatory diseases such as mastitis that impact all mammals, including humans. Definition of unique attributes of NETosis in ruminants, in comparison to what has been observed in humans, has significant translational implications for one health and global food security, and thus warrants further study. View Full-Text
Keywords: neutrophil extracellular traps NETs; neutrophils; pathogens; humans; ruminants; health; therapy neutrophil extracellular traps NETs; neutrophils; pathogens; humans; ruminants; health; therapy
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MDPI and ACS Style

Worku, M.; Rehrah, D.; Ismail, H.D.; Asiamah, E.; Adjei-Fremah, S. A Review of the Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat Models. Int. J. Mol. Sci. 2021, 22, 8046. https://doi.org/10.3390/ijms22158046

AMA Style

Worku M, Rehrah D, Ismail HD, Asiamah E, Adjei-Fremah S. A Review of the Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat Models. International Journal of Molecular Sciences. 2021; 22(15):8046. https://doi.org/10.3390/ijms22158046

Chicago/Turabian Style

Worku, Mulumebet, Djaafar Rehrah, Hamid D. Ismail, Emmanuel Asiamah, and Sarah Adjei-Fremah. 2021. "A Review of the Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat Models" International Journal of Molecular Sciences 22, no. 15: 8046. https://doi.org/10.3390/ijms22158046

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