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Review

Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch

by 1,†, 1,† and 1,2,3,*
1
Department of Neurology, Duke University, Durham, NC 27710, USA
2
Department of Anesthesiology, Duke University, Durham, NC 27710, USA
3
Department of Pathology, Duke University, Durham, NC 27710, USA
*
Author to whom correspondence should be addressed.
Co-first authors.
Academic Editor: Asia Fernandez Carvajal
Int. J. Mol. Sci. 2021, 22(14), 7591; https://doi.org/10.3390/ijms22147591
Received: 19 June 2021 / Revised: 12 July 2021 / Accepted: 13 July 2021 / Published: 15 July 2021
(This article belongs to the Section Molecular Neurobiology)
Itch is a clinical problem that leaves many sufferers insufficiently treated, with over 20 million cases in the United States. This is due to incomplete understanding of its molecular, cellular, and cell-to-cell signaling mechanisms. Transient receptor potential (TRP) ion channels are involved in several sensory modalities including pain, vision, taste, olfaction, hearing, touch, and thermosensation, as well as itch. Relative to the extensive studies on TRPV1 and TRPA1 ion channels in itch modulation, TRPV4 has received relatively little research attention and its mechanisms have remained poorly understood until recently. TRPV4 is expressed in ganglion sensory neurons and a variety of skin cells. Growing evidence in the past few years strongly suggests that TRPV4 in these cells contributes to acute and chronic disease-associated itch. This review focuses on the current experimental evidence involving TRPV4 in itch under pathophysiological conditions and discusses its possible cellular and molecular mechanisms. View Full-Text
Keywords: TRPV4; itch; keratinocytes; sensory neurons; pruritogen TRPV4; itch; keratinocytes; sensory neurons; pruritogen
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MDPI and ACS Style

Zhang, Q.; Henry, G.; Chen, Y. Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch. Int. J. Mol. Sci. 2021, 22, 7591. https://doi.org/10.3390/ijms22147591

AMA Style

Zhang Q, Henry G, Chen Y. Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch. International Journal of Molecular Sciences. 2021; 22(14):7591. https://doi.org/10.3390/ijms22147591

Chicago/Turabian Style

Zhang, Qiaojuan, Gwendolyn Henry, and Yong Chen. 2021. "Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch" International Journal of Molecular Sciences 22, no. 14: 7591. https://doi.org/10.3390/ijms22147591

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