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Article

In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers

1
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland
2
Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland
3
Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland
4
Instituto de Catalisis y Petroleoquimica, CSIC (Spanish National Research Council), Calle de Marie Curie, 2, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Hidayat Hussain
Int. J. Mol. Sci. 2021, 22(13), 7238; https://doi.org/10.3390/ijms22137238
Received: 28 May 2021 / Revised: 28 June 2021 / Accepted: 29 June 2021 / Published: 5 July 2021
(This article belongs to the Collection Anticancer Drug Discovery and Development)
Cancer is one of the deadliest illness globally. Searching for new solutions in cancer treatments is essential because commonly used mixed, targeted and personalized therapies are sometimes not sufficient or are too expensive for common patients. Sugar fatty acid esters (SFAEs) are already well-known as promising candidates for an alternative medical tool. The manuscript brings the reader closer to methods of obtaining various SFAEs using combined biological, chemical and enzymatic methods. It presents how modification of SFAE’s hydrophobic chains can influence their cytotoxicity against human skin melanoma and prostate cancer cell lines. The compound’s cytotoxicity was determined by an MTT assay, which followed an assessment of SFAEs’ potential metastatic properties in concentrations below IC50 values. Despite relatively high IC50 values (63.3–1737.6 μM) of the newly synthesized SFAE, they can compete with other sugar esters already described in the literature. The chosen bioactives caused low polymerization of microtubules and the depolymerization of actin filaments in nontoxic levels, which suggest an apoptotic rather than metastatic process. Altogether, cancer cells showed no propensity for metastasis after treating them with SFAE. They confirmed that lactose-based compounds seem the most promising surfactants among tested sugar esters. This manuscript creates a benchmark for creation of novel anticancer agents based on 3-hydroxylated fatty acids of bacterial origin. View Full-Text
Keywords: anticancer agents; sugar esters; polyhydroxyalkanoates; fluorination; chemical modifications; melanoma; prostate cancer anticancer agents; sugar esters; polyhydroxyalkanoates; fluorination; chemical modifications; melanoma; prostate cancer
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MDPI and ACS Style

Snoch, W.; Wnuk, D.; Witko, T.; Staroń, J.; Bojarski, A.J.; Jarek, E.; Plou, F.J.; Guzik, M. In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers. Int. J. Mol. Sci. 2021, 22, 7238. https://doi.org/10.3390/ijms22137238

AMA Style

Snoch W, Wnuk D, Witko T, Staroń J, Bojarski AJ, Jarek E, Plou FJ, Guzik M. In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers. International Journal of Molecular Sciences. 2021; 22(13):7238. https://doi.org/10.3390/ijms22137238

Chicago/Turabian Style

Snoch, Wojciech, Dawid Wnuk, Tomasz Witko, Jakub Staroń, Andrzej J. Bojarski, Ewelina Jarek, Francisco J. Plou, and Maciej Guzik. 2021. "In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers" International Journal of Molecular Sciences 22, no. 13: 7238. https://doi.org/10.3390/ijms22137238

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