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Review

Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases

1
Department of Molecular & Cell Biology, University of California, Berkeley, 3060 Valley Life Sciences Bldg #3140, Berkeley, CA 94720-3140, USA
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MiZ Inc., 39899 Balentine Drive Suite 200, Newark, CA 94560, USA
3
Department of Research and Development, MiZ Company Limited, 2-19-15 Ofuna, Kamakura, Kanagawa 247-0056, Japan
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Faculty of Environment and Information Studies, Keio University, 5322 Endo, Fujisawa 252-0882, Japan
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Faculty of Data Science, Musashino University, 3-3-3 Ariake, Koto-Ku, Tokyo 134-8181, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Lorenza Speranza, Chiara D’Angelo and Sara Franceschelli
Int. J. Mol. Sci. 2021, 22(13), 7211; https://doi.org/10.3390/ijms22137211
Received: 15 June 2021 / Revised: 29 June 2021 / Accepted: 30 June 2021 / Published: 5 July 2021
(This article belongs to the Special Issue Biological Role of Oxidative Stress in Inflammatory Diseases)
Mibyou, or pre-symptomatic diseases, refers to state of health in which a disease is slowly developing within the body yet the symptoms are not apparent. Common examples of mibyou in modern medicine include inflammatory diseases that are caused by chronic inflammation. It is known that chronic inflammation is triggered by the uncontrolled release of proinflammatory cytokines by neutrophils and macrophages in the innate immune system. In a recent study, it was shown that molecular hydrogen (H2) has the ability to treat chronic inflammation by eliminating hydroxyl radicals (·OH), a mitochondrial reactive oxygen species (ROS). In doing so, H2 suppresses oxidative stress, which is implicated in several mechanisms at the root of chronic inflammation, including the activation of NLRP3 inflammasomes. This review explains these mechanisms by which H2 can suppress chronic inflammation and studies its applications as a protective agent against different inflammatory diseases in their pre-symptomatic state. While mibyou cannot be detected nor treated by modern medicine, H2 is able to suppress the pathogenesis of pre-symptomatic diseases, and thus exhibits prospects as a novel protective agent. View Full-Text
Keywords: hydrogen; pre-symptomatic disease; chronic inflammation; oxidative stress; inflammatory diseases; hydroxyl radicals; reactive oxygen species hydrogen; pre-symptomatic disease; chronic inflammation; oxidative stress; inflammatory diseases; hydroxyl radicals; reactive oxygen species
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MDPI and ACS Style

Yamamoto, H.; Ichikawa, Y.; Hirano, S.-i.; Sato, B.; Takefuji, Y.; Satoh, F. Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases. Int. J. Mol. Sci. 2021, 22, 7211. https://doi.org/10.3390/ijms22137211

AMA Style

Yamamoto H, Ichikawa Y, Hirano S-i, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases. International Journal of Molecular Sciences. 2021; 22(13):7211. https://doi.org/10.3390/ijms22137211

Chicago/Turabian Style

Yamamoto, Haru, Yusuke Ichikawa, Shin-ichi Hirano, Bunpei Sato, Yoshiyasu Takefuji, and Fumitake Satoh. 2021. "Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases" International Journal of Molecular Sciences 22, no. 13: 7211. https://doi.org/10.3390/ijms22137211

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