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Article

Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics

1
University Lyon, INSA Lyon, CNRS, UMR 5240, CEDEX, F-69621 Villeurbanne, France
2
Department of Chemistry, Imperial College London, London SW7 2AZ, UK
3
Faculty of Chemistry and Chemical Biology, Technische Universität Dortmund, 44227 Dortmund, Germany
4
Université Grenoble Alpes, LiPhy, CEDEX, F-38044 Grenoble, France
5
Institut Laue Langevin, F-38000 Grenoble, France
*
Author to whom correspondence should be addressed.
Academic Editor: Alexande Baykov
Int. J. Mol. Sci. 2021, 22(11), 6087; https://doi.org/10.3390/ijms22116087
Received: 30 April 2021 / Revised: 27 May 2021 / Accepted: 2 June 2021 / Published: 4 June 2021
The modification of archaeal lipid bilayer properties by the insertion of apolar molecules in the lipid bilayer midplane has been proposed to support cell membrane adaptation to extreme environmental conditions of temperature and hydrostatic pressure. In this work, we characterize the insertion effects of the apolar polyisoprenoid squalane on the permeability and fluidity of archaeal model membrane bilayers, composed of lipid analogues. We have monitored large molecule and proton permeability and Laurdan generalized polarization from lipid vesicles as a function of temperature and hydrostatic pressure. Even at low concentration, squalane (1 mol%) is able to enhance solute permeation by increasing membrane fluidity, but at the same time, to decrease proton permeability of the lipid bilayer. The squalane physicochemical impact on membrane properties are congruent with a possible role of apolar intercalants on the adaptation of Archaea to extreme conditions. In addition, such intercalant might be used to cheaply create or modify chemically resistant liposomes (archeaosomes) for drug delivery. View Full-Text
Keywords: polyisoprenoids; squalane; archaea; cell membrane; permeability; fluorescence polyisoprenoids; squalane; archaea; cell membrane; permeability; fluorescence
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MDPI and ACS Style

Salvador-Castell, M.; Brooks, N.J.; Winter, R.; Peters, J.; Oger, P.M. Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics. Int. J. Mol. Sci. 2021, 22, 6087. https://doi.org/10.3390/ijms22116087

AMA Style

Salvador-Castell M, Brooks NJ, Winter R, Peters J, Oger PM. Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics. International Journal of Molecular Sciences. 2021; 22(11):6087. https://doi.org/10.3390/ijms22116087

Chicago/Turabian Style

Salvador-Castell, Marta, Nicholas J. Brooks, Roland Winter, Judith Peters, and Philippe M. Oger 2021. "Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics" International Journal of Molecular Sciences 22, no. 11: 6087. https://doi.org/10.3390/ijms22116087

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