Next Article in Journal
Molecular Mechanisms of PD-1 and PD-L1 Activity on a Pan-Cancer Basis: A Bioinformatic Exploratory Study
Next Article in Special Issue
The Mechanism of Drug Nephrotoxicity and the Methods for Preventing Kidney Damage
Previous Article in Journal
The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture
Previous Article in Special Issue
Rapamycin Alternatively Modifies Mitochondrial Dynamics in Dendritic Cells to Reduce Kidney Ischemic Reperfusion Injury
Article

Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury

1
Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 37, 50937 Cologne, Germany
2
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne, Germany
3
Max Planck Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany
4
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEPD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany
5
Institute of Pathology, University Hospital of Cologne, Kerpener Str. 37, 50937 Cologne, Germany
*
Authors to whom correspondence should be addressed.
These Authors contributed equally to this work.
Academic Editors: Amandeep Bajwa and Navjot Pabla
Int. J. Mol. Sci. 2021, 22(11), 5485; https://doi.org/10.3390/ijms22115485
Received: 22 April 2021 / Revised: 12 May 2021 / Accepted: 18 May 2021 / Published: 22 May 2021
(This article belongs to the Special Issue Pathobiology of Acute Kidney Injury)
Acute kidney injury (AKI) is a frequent and critical complication in the clinical setting. In rodents, AKI can be effectively prevented through caloric restriction (CR), which has also been shown to increase lifespan in many species. In Caenorhabditis elegans (C. elegans), longevity studies revealed that a marked CR-induced reduction of endocannabinoids may be a key mechanism. Thus, we hypothesized that regulation of endocannabinoids, particularly arachidonoyl ethanolamide (AEA), might also play a role in CR-mediated protection from renal ischemia-reperfusion injury (IRI) in mammals including humans. In male C57Bl6J mice, CR significantly reduced renal IRI and led to a significant decrease of AEA. Supplementation of AEA to near-normal serum concentrations by repetitive intraperitoneal administration in CR mice, however, did not abrogate the protective effect of CR. We also analyzed serum samples taken before and after CR from patients of three different pilot trials of dietary interventions. In contrast to mice and C. elegans, we detected an increase of AEA. We conclude that endocannabinoid levels in mice are modulated by CR, but CR-mediated renal protection does not depend on this effect. Moreover, our results indicate that modulation of endocannabinoids by CR in humans may differ fundamentally from the effects in animal models. View Full-Text
Keywords: acute kidney injury; ischemia-reperfusion injury; preconditioning; caloric restriction; stress resistance; endocannabinoid; anandamide acute kidney injury; ischemia-reperfusion injury; preconditioning; caloric restriction; stress resistance; endocannabinoid; anandamide
Show Figures

Figure 1

MDPI and ACS Style

Hoyer-Allo, K.J.R.; Späth, M.R.; Hanssen, R.; Johnsen, M.; Brodesser, S.; Kaufmann, K.; Kiefer, K.; Koehler, F.C.; Göbel, H.; Kubacki, T.; Grundmann, F.; Schermer, B.; Brüning, J.; Benzing, T.; Burst, V.; Müller, R.-U. Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. Int. J. Mol. Sci. 2021, 22, 5485. https://doi.org/10.3390/ijms22115485

AMA Style

Hoyer-Allo KJR, Späth MR, Hanssen R, Johnsen M, Brodesser S, Kaufmann K, Kiefer K, Koehler FC, Göbel H, Kubacki T, Grundmann F, Schermer B, Brüning J, Benzing T, Burst V, Müller R-U. Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. International Journal of Molecular Sciences. 2021; 22(11):5485. https://doi.org/10.3390/ijms22115485

Chicago/Turabian Style

Hoyer-Allo, Karla J.R., Martin R. Späth, Ruth Hanssen, Marc Johnsen, Susanne Brodesser, Kathrin Kaufmann, Katharina Kiefer, Felix C. Koehler, Heike Göbel, Torsten Kubacki, Franziska Grundmann, Bernhard Schermer, Jens Brüning, Thomas Benzing, Volker Burst, and Roman-Ulrich Müller. 2021. "Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury" International Journal of Molecular Sciences 22, no. 11: 5485. https://doi.org/10.3390/ijms22115485

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop