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Article

Tandem Repeats in Bacillus: Unique Features and Taxonomic Distribution

Department of Computer Science, Polytechnic University of Catalonia, 08034 Barcelona, Spain
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Author to whom correspondence should be addressed.
Academic Editors: Miroslav Plohl, Eva Šatović and Raquel Chaves
Int. J. Mol. Sci. 2021, 22(10), 5373; https://doi.org/10.3390/ijms22105373
Received: 20 April 2021 / Revised: 14 May 2021 / Accepted: 18 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Repetitive DNA Sequences in Eukaryotic Genomes)
Little is known about DNA tandem repeats across prokaryotes. We have recently described an enigmatic group of tandem repeats in bacterial genomes with a constant repeat size but variable sequence. These findings strongly suggest that tandem repeat size in some bacteria is under strong selective constraints. Here, we extend these studies and describe tandem repeats in a large set of Bacillus. Some species have very few repeats, while other species have a large number. Most tandem repeats have repeats with a constant size (either 52 or 20–21 nt), but a variable sequence. We characterize in detail these intriguing tandem repeats. Individual species have several families of tandem repeats with the same repeat length and different sequence. This result is in strong contrast with eukaryotes, where tandem repeats of many sizes are found in any species. We discuss the possibility that they are transcribed as small RNA molecules. They may also be involved in the stabilization of the nucleoid through interaction with proteins. We also show that the distribution of tandem repeats in different species has a taxonomic significance. The data we present for all tandem repeats and their families in these bacterial species will be useful for further genomic studies. View Full-Text
Keywords: tandem repeats; satellites; Bacillus; Bacillus coagulans; bacteria; non-coding DNA; bacterial nucleoid; small RNA tandem repeats; satellites; Bacillus; Bacillus coagulans; bacteria; non-coding DNA; bacterial nucleoid; small RNA
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MDPI and ACS Style

Subirana, J.A.; Messeguer, X. Tandem Repeats in Bacillus: Unique Features and Taxonomic Distribution. Int. J. Mol. Sci. 2021, 22, 5373. https://doi.org/10.3390/ijms22105373

AMA Style

Subirana JA, Messeguer X. Tandem Repeats in Bacillus: Unique Features and Taxonomic Distribution. International Journal of Molecular Sciences. 2021; 22(10):5373. https://doi.org/10.3390/ijms22105373

Chicago/Turabian Style

Subirana, Juan A., and Xavier Messeguer. 2021. "Tandem Repeats in Bacillus: Unique Features and Taxonomic Distribution" International Journal of Molecular Sciences 22, no. 10: 5373. https://doi.org/10.3390/ijms22105373

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