Analysis of Results of Specific IgE in 100 Atopic Dermatitis Patients with the Use of Multiplex Examination ALEX2—Allergy Explorer
Abstract
:1. Introduction
2. Results
- Blo t 5—Storage mites, Blomia tropicalis
- Aca s—Storage mites, Acarus siro
- Gly d 2, Lep d 2—Storage mites, NPC2 family
- Can f 1, Can f 2, Can f 4 and Can f 6—Lipocalins
- Fel d 1, Ory c 3—Uteroglobin
- Mala s 11—Mn superoxide dismutase
- Asp f 6, Bla g 9, Der p 20, Pen m 2—Arginine kinase
- Fag s 1, Mal d 1, Cor a 1.0401, Cor a 1.0103—PR-10 proteins
- Cyn d 1, Lol p 1, Phl p 1—Beta-expansins
- Phl p 2—Expansin
- Der p 21, Der p 23—Peritrophin-like domain.
- Secc pollen—Cultivated rye
- Cra c 6—Troponin C (North Sea shrimp)
- Hom g—Lobster
- Ara h 6-2S Albumin, Peanut, Ara h 1-Cupin (Vicillin-type, 7S globulin), Peanut
- Alt a 6—Enolase, Alternaria alternata
- Lep d 2, Der p 2, Der f 2—NPC2 family
- Der p 1—Cystein protease
- Der p 21, Der p 23—Peritrophin-like protein domain
- Der p 5, Der p 7—European house dust mite
- Loc m—Migratory locust
- Phl p 1—Beta expansin
- Phl p 2—Expansin
- Secc pollen—Cultivated rye
- Tyr p—Storage mite
- Api g 1, Bet v 1, Cor a 1.0103, rCor a 1.0401, Dau c 1, Fag s 1—PR-10 proteins
- Cyn d 1—Beta expansin
- Can f—1 Lipocalin
- Fel d 1—Uteroglobin
- Der f 1—Cystein proteasa
- Phl p 5, Phl p 6—Grass group 5, 6 Timothy.
- Can f 1, Can f 2, Can f 4, Cav p 1, Fel d 4, Fel d 7—Lipocalins
- Phl p 1—Beta expansin
- Phl p 2—Expansin
- Fel d 1—Uteroglobin
- Der p 21, Der p 5—House dust mites and
- Asp f 6—Mn superoxide dismutase, Aspergillus fumigatus
- Der f 2, Der p 2—NPC2 family, house dust mite
- Fel d 1—Uteroglobin
- Fel d 4, Mus m 1—Lipocalins
- Mala s 5—Malassezia sympodialis
- Rat—extract specific IgE of Rat
- Aca s, Blo t 5, Tyr p—Storage mites
- Pen m 2, Der p 20, Bla g 9—Arginine kinase
- Asp f 6—Mn superoxide dismutase, Aspergillus fumigatus
- Der f 2, Der p 2—NPC2 family, house dust mite
- Gly d 2 and Lep d 2—NPC2 family, storage mite
- Der p 5, Der p 7, Der p21—Molecular components from house dust mites
- Der p 23—Peritrophin-like domain
- Can f Fel d 1-like—Uteroglobin
- Cor a 1.0103, Fag s1—PR-10 proteins
- Phl p 1—Beta expansin
- Phl p 2—Expansin
2.1. Comparison of Mild and Severe Form of AD
2.2. Comparison of Mild and Moderate Forms of AD
2.3. Comparison of Moderate and Severe Forms of AD
3. Discussion
4. Materials and Methods
4.1. Statistical Analysis
4.2. Commentary on Statistical Evaluation
4.3. Patients and Methods
4.4. Dermatological Examination
4.5. Examination of SpecificIgE to Molecular Components
4.6. Bronchial Asthma
4.7. Allergic Rhinitis
4.8. The Evaluation of Duration of Atopic Dermatitis
4.9. The Onset of Atopic Dermatitis
4.10. The Family History of Atopy
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic of Patients | Number of Patients |
---|---|
Patients suffering from atopic dermatitis | 100 patients |
Sex | 48 men, 52 women |
The average age | 40.9 years (min. age 14 years, max. age 67 years) |
The average SCORAD | 39 points, s.d. 13.1 points |
Severity of AD | Mild form 14 (14%) |
Moderate form 61 (61%) | |
Severe form 25 (25%) | |
Family history about atopy | Positive family history 48 patients (48%) |
Negative family history 52 patients (52%) | |
Onset of AD | Under 5 years of age 61 patients (61%) |
After 5 year of age 39 patients (%) | |
Eczematic lesions | Persistent 57 patients (57%) |
Occasional 43 patients (43%) | |
Bronchial asthma | 55 (55%) |
Allergic rhinitis | 74 (74%) |
Allergen Reagents (Allergenic Extracts and Molecular Components) | Sensitization Confirmed in Patients (%) |
---|---|
Phl p 1 (Beta expansin, Timothy grass) | 57.0 |
Bet v 1 (PR-10 protein, birch), Lol p 1 (Beta expansin, rye grass), Sec c_pollen (cultivated rye, pollen) | 53.0 |
Fag s1 (PR-10 protein, European beech) | 49.0 |
Cor a 1.0103 (PR-10 protein, hazel pollen) Cyn d 1 (Beta expansin, Bermuda grass) | 48.0 |
Cor a_pollen (hazel pollen) | 47.0 |
Der f 2 (NPC2 family, house dust mite) Fra a 1 + 3 (PR-10 protein + non-specific lipid transfer protein, type 1, strawberry) Phl p 2 (expansin, Timothy grass) | 45.0 |
Cor a 1.0401 (PR-10 protein, hazel pollen) Cyn d (Bermuda grass) Der p 2 (NPC2 family, house dust mite) Fel d 1 (uteroglobin, cat) | 44.0 |
Aln g 1 (PR-10 protein, alder) | 43.0 |
Pas n (bahia grass) Phl p 5.0101 (grass group 5/6, Timothy grass), Phl p 6 (grass group 5/6, Timothy grass) | 42.0 |
Lep d 2 (NPC2 family, storage mite) Mal d 1 (PR-10 protein, apple) | 41.0 |
Can f 1 (lipocalin, dog) Der p 23 (peritrophin-like protein domain, house dust mite) | 36.0 |
Gly m 4 (PR-10 protein, soybean) | 35.0 |
Der p 1 (cysteine protease, house dust mite) | 34.0 |
Ara h 8 (PR-10 protein, peanut) Gly d 2 (NPC2 family, storage mite) | 33.0 |
Art v (mugwort), Can f 6 (lipocalin, dog) | 32.0 |
Der f 1 (cysteine protease, house dust mite) Fel d 7 (lipocalin, cat) | 31.0 |
Can f_male urine (male dog urine) | 30.0 |
Can f 4 (lipocalin, dog) Equ c 1 (lipocalin, horse) | 29.0 |
Pla l (English plantain) | 28.0 |
Ory c 3 (uteroglobin, rabbit) Phr c (common reed) | 27.0 |
Aca s (storage mite) Alt a 1 (unknown, Alternaria alternata) Der p 5 (unknown, house dust mite) Fel d 4 (lipocalin, cat) | 26.0 |
Amb a (ragweed) Tyr p (storage mite) | 25.0 |
Ach d (house cricket) Der p 7 (mites group 7, bactericidal permeability-increasing-like protein, house dust mite) Loc m (migratory locust) Mala s 11 (Mn superoxide dismutase, Malassezia sympodialis) | 24.0 |
Amb a 4 (plant defensin, ragweed) Der p 20 (arginine kinase, house dust mite), Ten m (mealworm) | 23.0 23.0 |
Api g 1 (PR-10 protein, celery), Mus m 1 (lipocalin and urinary prealbumin, house mouse) | 22.0 |
Bla g 9 (arginine kinase, German cockroach) Can f_Fd1 (uteroglobin, dog), Cav p 1 (lipocalin, guinea pig) | 21.0 |
Asp f 6 (Mn superoxide dismutase, Aspergillus fumigatus) Bla g 4 (calycin, lipocalin, German cockroach) Fra e 1 (Ole e 1-like protein family, European ash), Jug r_pollen (walnut pollen) | 20.0 |
Art v 1 (plant defensin, mugwort) Dau c (carrot) Dau c 1 (PR-10 protein, carrot) | 19.0 |
Par j 2 (non-specific lipid transfer protein, type 1, pellitory of the wall) Pen m 2 (arginine kinase, shrimp) Ves v 5 (antigen 5, yellow jacket venom) | 18.0 |
Ama r (redroot pigweed) Can f 2 (lipocalin, dog) Rat n (rat) | 17.0 |
Api m (honey bee venom) Cup a 1 (pectate lyase, cypress) Fra e (European ash), Gal d_white (egg white) Per a (American cockroach) | 16.0 |
Aca m (acacia) Api m 1 (phospholipase A2, honey bee venom) Asp f 3 (peroxysomal protein, Aspergillus fumigatus) Cla h 8 (mannitol dehydrogenase, cladosporium herbarum) Cry j 1 (pectate lyase, Japanese cedar) Der p 21 (unknown, house dust mite) Hel a (sunflower seed) Hom g (lobster) Pla l 1 (Ole e 1-like protein family, English plantain) Sal k (Russian thistle, saltwort) | 15.0 |
Act d 2 (thaumatin-like protein, kiwi fruit) Mala s 6 (cyclophilin, malassezia sympodialis) Sac c (Saccharomyces cerevisiae) Sol t (potato) | 14.0 |
Api m 10 (icarapin variant 2, honey bee venom) Pha v (green bean, French bean) | 13.0 |
Alt a 6 (enolase, Alternaria alternata) Amb a 1 (pectate lyase, ragweed), Api g 2 (non-specific lipid transfer protein, type 1, celery) Blo t 5 (mites group 5, storage mite) Can s (hemp), Hor v (barley) Lol spp. (squid) Pan b (Northern shrimp), Phl p 7 (polcalcin, Timothy grass) Phod s 1 (lipocalin, Siberian hamster) Sal k 1 (pectin methylesterase, Russian thistle, saltwort) Urt d (nettle) | 12.0 |
Bet v 2 (profilin, birch) Cuc m 2 (profilin, muskmelon) Pec spp. (scallop) Sec c_flour (cultivated rye) Ses i 1 (2S albumin, sesame) Tyr p 2 (NPC2 family, storage mite) Ves v (yellow jacket venom), Ves v 1 (phospholipase A1, yellow jacket venom) Zea m 14 (non-specific lipid transfer protein, type 1, maize) | 11.0 |
Che q (quinoa) Mala s 5 (unknown, Malassezia sympodialis) Ole e 1 (Ole e 1-family, olive) Pers a (avocado) Phl p 12 (profilin, Timothy grass) Pla a 2 (polygalacturonase, London plane tree) Pol d (paper wasp venom) Pyr c (pear) Sola l (tomato) Ulm c (elm) Zea m (maize) | 10.0 |
The Number of Patients According to the Level of Specific IgE in Classes 0–4 in 75 Selected Allergen Reagents, (100 Patients Included in the Study = 100%) | ||||||
---|---|---|---|---|---|---|
Allergen Reagents (Allergen Extract, Molecular Components) | Class 0 | Class 1 | Class 2 | Class 3 | Class 4 | Class 3 + Class 4 |
Acas | 74 | 5 | 7 | 8 | 6 | 14 |
Achd | 76 | 6 | 3 | 7 | 8 | 15 |
Alng1 | 57 | 0 | 12 | 14 | 17 | 31 |
Alta1 | 74 | 0 | 0 | 4 | 22 | 26 |
Alta6 | 88 | 2 | 4 | 4 | 2 | 6 |
Amba | 75 | 5 | 8 | 8 | 4 | 12 |
Amba4 | 77 | 7 | 5 | 8 | 3 | 11 |
Apig1 | 78 | 5 | 3 | 8 | 6 | 14 |
Apim10 | 87 | 6 | 1 | 6 | 0 | 6 |
Arah8 | 67 | 8 | 10 | 8 | 7 | 15 |
Artv | 68 | 5 | 7 | 10 | 10 | 20 |
Artv1 | 81 | 2 | 7 | 9 | 1 | 10 |
Aspf6 | 80 | 2 | 4 | 9 | 5 | 14 |
Betv1 | 47 | 2 | 6 | 5 | 40 | 45 |
Blag9 | 79 | 0 | 1 | 2 | 18 | 20 |
Blot5 | 88 | 3 | 3 | 3 | 3 | 6 |
Canf_Fd1 | 79 | 6 | 9 | 6 | 0 | 6 |
Canf_maleurine | 70 | 2 | 8 | 7 | 13 | 20 |
Canf1 | 64 | 1 | 8 | 10 | 17 | 27 |
Canf2 | 83 | 1 | 2 | 4 | 10 | 14 |
Canf4 | 71 | 1 | 6 | 5 | 17 | 22 |
Canf6 | 68 | 0 | 6 | 5 | 21 | 26 |
Cavp1 | 79 | 1 | 4 | 7 | 9 | 16 |
Cora_pollen | 53 | 4 | 7 | 19 | 17 | 36 |
Cora1.0103 | 52 | 2 | 7 | 7 | 32 | 39 |
Cora1.0401 | 56 | 0 | 14 | 10 | 20 | 30 |
Cynd | 56 | 12 | 16 | 14 | 2 | 16 |
Cynd1 | 52 | 8 | 16 | 16 | 8 | 24 |
Dauc | 81 | 6 | 3 | 7 | 3 | 10 |
Dauc1 | 81 | 5 | 2 | 6 | 6 | 12 |
Derf1 | 69 | 3 | 5 | 12 | 11 | 23 |
Derf2 | 55 | 1 | 2 | 2 | 40 | 42 |
Derp1 | 66 | 2 | 7 | 7 | 18 | 25 |
Derp2 | 56 | 0 | 2 | 2 | 40 | 42 |
Derp20 | 77 | 2 | 2 | 1 | 18 | 19 |
Derp21 | 85 | 0 | 1 | 2 | 12 | 14 |
Derp23 | 64 | 1 | 7 | 5 | 23 | 28 |
Derp5 | 74 | 8 | 3 | 1 | 14 | 15 |
Derp7 | 76 | 6 | 12 | 3 | 3 | 6 |
Equc1 | 71 | 2 | 8 | 1 | 18 | 19 |
Fags1 | 51 | 3 | 6 | 15 | 25 | 40 |
Feld1 | 56 | 4 | 6 | 2 | 32 | 34 |
Feld4 | 74 | 3 | 8 | 6 | 9 | 15 |
Feld7 | 69 | 5 | 10 | 3 | 13 | 16 |
Fraa13 | 55 | 6 | 13 | 12 | 14 | 26 |
Frae | 84 | 2 | 4 | 2 | 8 | 10 |
Frae1 | 80 | 4 | 5 | 2 | 9 | 11 |
Glyd2 | 67 | 9 | 8 | 4 | 12 | 16 |
Glym4 | 65 | 7 | 12 | 8 | 8 | 16 |
Homg | 85 | 2 | 7 | 2 | 4 | 6 |
Chispp_ | 91 | 1 | 2 | 3 | 3 | 6 |
Lepd2 | 59 | 4 | 9 | 18 | 10 | 28 |
Locm | 76 | 8 | 6 | 4 | 6 | 10 |
Lolp1 | 47 | 7 | 6 | 10 | 30 | 40 |
Malas11 | 76 | 0 | 7 | 1 | 16 | 17 |
Malas5 | 90 | 1 | 3 | 1 | 5 | 6 |
Mald1 | 59 | 1 | 17 | 10 | 13 | 23 |
Musm1 | 78 | 1 | 6 | 7 | 8 | 15 |
Olee1 | 90 | 0 | 3 | 2 | 5 | 7 |
Oryc3 | 73 | 1 | 2 | 10 | 14 | 24 |
Panb | 88 | 0 | 5 | 5 | 2 | 7 |
Pasn | 58 | 9 | 19 | 12 | 2 | 14 |
Penm2 | 82 | 0 | 6 | 5 | 7 | 12 |
Phlp1 | 43 | 5 | 9 | 4 | 39 | 43 |
Phlp2 | 55 | 4 | 9 | 7 | 25 | 32 |
Phlp5_0101 | 58 | 0 | 5 | 5 | 32 | 37 |
Phlp6 | 58 | 7 | 6 | 8 | 21 | 29 |
Phods1 | 88 | 3 | 2 | 2 | 5 | 7 |
Plal | 72 | 14 | 2 | 2 | 10 | 12 |
Plal1 | 85 | 3 | 0 | 2 | 10 | 12 |
Ratn | 83 | 3 | 6 | 6 | 2 | 8 |
Secc_pollen | 47 | 5 | 17 | 17 | 14 | 31 |
Tenm | 77 | 7 | 6 | 6 | 4 | 10 |
tIgE | 18 | 0 | 0 | 0 | 82 | 82 |
Tyrp | 75 | 5 | 7 | 8 | 5 | 13 |
Allergen Reagents, Allergenic Extracts and Molecular Components (Biochemical Name). r = Recombinant, n= Natural | Number of Patients | Severity of AD | Bronchial Asthma | Allergic Rhinitis | Onset of AD | Family History | Duration of Lesion | |
---|---|---|---|---|---|---|---|---|
Aca s | Storage mite | 14 | 0.0437 | - | - | - | - | 0.00316 |
Ach d | House cricket | 15 | - | - | - | - | - | 0.00164 |
rAln g 1 | PR-10 protein, alder | 31 | - | - | - | - | - | - |
rAlt a 1 | Unknown, Alternaria alternata | 26 | - | - | - | - | - | - |
rAlt a 6 | Enolase, Alternaria alternata | 6 | - | 0.0312 | - | - | - | - |
Amb a | Ragweed | 12 | - | - | - | - | - | - |
rAmb a 4 | Plant defensin, ragweed | 11 | - | - | - | - | - | - |
rApi g 1 | PR-10 protein, celery | 14 | - | - | 0.0182 | - | - | - |
rApi m 10 | Icarapin variant 2, honey bee venom | 6 | - | - | - | - | - | |
nAra h 1 | Cupin (vicillin-type, 7S globulin), peanut | 5 | 0.0349 | - | - | - | - | - |
nAra h 6 | 2S albumin, peanut | 5 | 0.0349 | - | - | - | - | - |
rAra h 8 | PR-10 protein, peanut | 15 | - | - | - | - | - | - |
Art v | Mugwort | 20 | - | - | - | - | - | - |
rArt v 1 | Plant defensin, mugwort | 10 | - | - | - | - | - | - |
rAsp f 6 | Mn superoxide dismutase, Aspergillus fumigatus | 14 | 0.00145 | - | - | 0.00784 | - | 0.0214 |
rBet v 1 | PR-10 protein, birch | 45 | - | - | 0.009 | - | - | - |
rBla g 9 | Arginine kinase, German cockroach | 20 | 0.00439 | - | - | - | - | 0.0008 |
rBlo t 5 | Blomia tropicalis, storage mite | 6 | 0.023 | - | - | - | - | 0.0356 |
rCan f 1 | Lipocalin, dog | 27 | 0.0235 | - | 0.01 | 0.00262 | - | - |
rCan f 2 | Lipocalin, dog | 14 | 0.0437 | - | - | 0.00784 | - | - |
rCan f 4 | Lipocalin, dog | 22 | - | - | - | 0.00623 | - | - |
rCan f 6 | Lipocalin, dog | 26 | 0.00907 | - | - | - | - | - |
rCanf_Fel d 1-like | Uteroglobin, dog | 6 | - | - | - | - | - | 0.0356 |
Can f_male urine | Male dog urine | 20 | - | - | - | - | - | - |
rCav p 1 | Lipocalin, guinea pig | 16 | - | - | 0.0238 | |||
rCor a 1.0103 | PR-10 protein, hazel pollen | 39 | 0.0163 | - | 0.0163 | - | - | 0.0482 |
rCor a 1.0401 | PR-10 protein, hazelnut | 30 | 0.00819 | - | - | - | - | - |
Cor a_pollen | Hazel pollen | 36 | 0.00728 | - | 0.0164 | - | - | 0.0211 |
rCra c 6 | Troponin C, North sea shrimp | 5 | 0.0349 | - | - | - | - | - |
Cyn d | Bermuda grass | 16 | 0.0288 | - | - | - | - | - |
rCyn d 1 | Beta expansin, Bermuda grass | 24 | 0.00168 | - | 0.0312 | - | - | |
Dau c | Carrot | 10 | - | - | - | - | - | 0.0402 |
rDau c 1 | PR-10 protein, carrot | 12 | - | - | 0.0329 | - | - | - |
rDer f 1 | Cysteine protease, house dust mite | 23 | - | - | 0.0327 | - | - | - |
rDer f 2 | NPC2 family, house dust mite | 42 | 0.046 | 0.0497 | 0.0384 | |||
rDer p 1 | Cysteine protease, house dust mite | 25 | - | 0.0485 | - | - | - | - |
rDer p 2 | NPC2 family, house dust mite | 42 | 0.046 | - | - | 0.0497 | 0.0384 | |
rDer p 20 | Arginine kinase, house dust mite | 19 | 0.00224 | - | - | - | - | 0.00017 |
rDer p 21 | Unknown, house dust mite | 14 | 0.0437 | 0.0185 | - | 0.00784 | - | 0.00316 |
rDer p 23 | Peritrophin-like protein domain, house dust mite | 28 | 0.00785 | 0.0122 | - | - | - | 0.00658 |
rDer p 5 | Unknown, house dust mite | 15 | - | 0.0482 | - | 0.042 | - | 0.00164 |
rDer p 7 | Bactericidal permeability-increasing-like protein, house dust mite | 6 | - | 0.0312 | - | - | - | 0.0356 |
rEqu c 1 | Lipocalin, horse | 19 | - | - | - | - | - | - |
rFag s 1 | PR-10 protein, European beech | 40 | 0.017 | - | 0.0189 | - | - | 0.032 |
rFel d 1 | Uteroglobin, cat | 34 | 0.0319 | 0.0291 | 0.00168 | 0.00117 | 0.00476 | |
rFel d 4 | Lipocalin, cat | 15 | - | - | - | 0.042 | 0.00713 | - |
rFel d 7 | Lipocalin, cat | 16 | - | - | - | 0.00017 | - | - |
rFra a 1 + 3 | PR-10 protein+ non-specific lipid transfer protein type 1, strawberry | 26 | - | - | - | - | - | - |
Fra e | European ash | 10 | - | - | - | - | - | - |
rFra e 1 | Ole e 1-like protein family, European ash | 11 | - | - | - | - | - | - |
rGly d 2 | NPC2 family, storage mite | 16 | 0.0455 | - | - | - | - | 0.00085 |
rGly m 4 | PR-10 protein, soybean | 16 | - | - | - | - | - | - |
Hom g | Lobster | 6 | 0.0337 | - | - | - | - | - |
Chi spp. | Crab | 6 | - | - | - | - | - | - |
rLep d 2 | NPC2 family, storage mite | 28 | 0.0168 | 0.0462 | - | - | - | 0.00154 |
Loc m | Migratory locust | 10 | - | 0.0402 | - | - | - | 0.0402 |
nLol p 1 | Beta-espansin, Rye grass | 40 | 0.0132 | 0.0406 | 0.0106 | |||
Lol spp. | Squid | 5 | - | - | - | - | - | - |
rMal d 1 | PR-10 protein, apple | 23 | 0.0249 | - | - | - | - | - |
rMala s 11 | Mn superoxide dismutase, Malassezia sympodialis | 17 | 0.00855 | - | - | - | - | - |
rMala s 5 | Unknown, Malassezia sympodialis | 6 | - | - | - | - | 0.0103 | - |
nMus m 1 | Lipocalin and urinary prealbumin, house mouse | 15 | - | - | - | - | 0.00147 | - |
nOle e 1 | Ole e 1-family, olive | 7 | - | - | - | - | - | 0.0185 |
rOry c 1 | Lipocalin, rabbit | 5 | - | - | - | - | - | - |
rOry c 3 | Uteroglobin, rabbit | 24 | 0.0431 | - | - | - | - | 0.041 |
Pan b | Northern shrimp | 7 | - | - | - | - | - | - |
Pas n | Bahia grass | 14 | 0.0437 | - | - | - | - | - |
rPen m 2 | Arginine kinase, shrimp | 12 | 0.0264 | - | - | - | - | 0.001 |
rPer a 7 | Tropomyosin, American cockroach | 5 | - | - | - | - | - | - |
rPhl p 1 | Beta expansin, Timothy | 43 | 0.0273 | 0.0298 | - | 0.0482 | - | 0.0251 |
rPhl p 2 | Expansin, Timothy | 32 | 0.0164 | 0.02 | - | 0.049 | - | 0.0126 |
rPhl p 5.0101 | Grass group 5/6, Timothy | 37 | - | - | 0.0291 | - | - | 0.04 |
rPhl p 6 | Grass group 5/6, Timothy | 29 | - | - | 0.0248 | - | - | - |
rPhod s 1 | Lipocalin, Siberian hamster | 7 | - | - | - | - | - | - |
Pla l | English plantain | 12 | - | - | - | - | - | - |
rPla l 1 | Ole e 1-like protein family, English plantain | 12 | - | - | - | - | - | - |
Rat n | Rat | 8 | - | - | - | - | 0.0267 | - |
Sec c_pollen | Cultivated rye, pollen | 31 | 0.0118 | 0.00971 | - | - | - | - |
Ten m | Mealworm | 10 | - | - | - | - | - | 0.0402 |
Tyr p | Storage mite | 13 | - | 0.0338 | - | - | - | 0.00604 |
rXip g 1 | Beta-parvalbumin, swordfish | 5 | - | - | - | - | - | - |
Comparison of Column Proportions | ||||
---|---|---|---|---|
Allegen Reagents | The Level of Specific IgE in Classes 0–4 | Mild Form of AD (A) | Moderate Form of AD (B) | Severe Form of AD (C) |
Acam | 0 | .a | C(0.023) | |
1 | .a | B(0.022) | ||
Acas | 0 | C(0.030) | C(0.004) | |
Allc | 0 | .a | C(0.035) | |
Alta6 | 0 | .a | ||
3 | .a | B(0.038) | ||
Amar | 0 | .a | C(0.016) | |
1 | .a | |||
2 | .a | B(0.010) | ||
Amba | 0 | |||
4 | .a | B(0.038) | ||
Apig1 | 0 | C(0.047) | C(0.047) | |
Arah1 | 0 | .a | C(0.009) | |
4 | .a | B(0.038) | ||
Arah2 | 0 | .a | C(0.038) | |
Arah3 | 0 | .a | C(0.038) | |
Aspf1 | 0 | .a | C(0.038) | |
Aspf6 | 0 | .a | C(0.019) | |
3 | .a | B(0.009) | ||
Betv1 | 0 | |||
2 | B(0.040) | .a | ||
4 | A(0.017) | |||
Betv2 | 0 | .a | C(0.046) | |
Blag4 | 0 | .a | C(0.019) | |
1 | .a | |||
2 | .a | B(0.009) | ||
Blag9 | 0 | C(0.025) | C(0.011) | |
2 | .a | .a | ||
3 | .a | .a | ||
4 | A(0.025) B(0.001) | |||
Blot21 | 0 | .a | C(0.010) | |
Blot5 | 0 | C(0.021) | ||
Canf1 | 0 | B(0.032) C(0.032) | ||
Canf2 | 0 | .a | ||
3 | .a | B(0.038) | ||
Canf6 | 0 | C(0.015) | ||
4 | A(0.043) B(0.043) | |||
Capa | 0 | .a | C(0.029) | |
Carp | 0 | .a | C(0.038) | |
Clah | 0 | .a | C(0.002) | |
1 | .a | B(0.010) | ||
Clah8 | 0 | .a | C(0.023) | |
4 | A(0.015) | |||
Crac6 | 0 | C(0.007) | ||
Cucm2 | 0 | .a | C(0.046) | |
Cupa1 | 0 | .a | C(0.041) | |
1 | .a | B(0.035) | ||
Cynd | 0 | C(0.008) | ||
Cynd1 | 0 | C(0.016) | ||
4 | .a | B(0.029) | ||
1 | .a | B(0.035) | ||
Derf2 | 0 | C(0.032) | ||
Derp20 | 0 | C(0.014) | C(0.007) | |
4 | A(0.025) B(0.001) | |||
Derp21 | 0 | |||
4 | .a | B(0.016) | ||
Derp23 | 0 | |||
4 | .a | B(0.021) | ||
Dolspp | 0 | .a | C(0.038) | |
Equc1 | 0 | C(0.015) | C(0.021) | |
Equc3 | 0 | .a | C(0.038) | |
Fags1 | 0 | |||
2 | B(0.040) | .a | ||
Feld4 | 0 | C(0.008) | C(0.008) | |
4 | B(0.008) | |||
Fraa1 + 3 | 0 | C(0.032) | ||
Frae | 0 | C(0.011) | ||
Frae1 | 0 | C(0.016) | ||
Gadm | 0 | .a | C(0.038) | |
Gald1 | 0 | .a | C(0.002) | |
Gald2 | 0 | .a | C(0.001) | |
2 | .a | B(0.038) | ||
Gald3 | 0 | .a | C(0.010) | |
2 | .a | B(0.038) | ||
Gald5 | 0 | .a | C(0.010) | |
Gald_white | 0 | .a | C(0.008) | |
Gald_yolk | 0 | .a | C(0.002) | |
1 | .a | B(0.038) | ||
Glyd2 | 0 | |||
4 | B(.021) | |||
Glym4 | 0 | |||
4 | .a | B(.029) | ||
Hela | 0 | .a | C(.004) | |
1 | .a | B(.001) | ||
Hevb8 | 0 | .a | C(.003) | |
4 | .a | B(.038) | ||
Horv | 0 | .a | C(.016) | |
Chea | 0 | .a | C(.002) | |
Cheq | 0 | .a | ||
2 | .a | B(0.038) | ||
Jugr_pollen | 0 | .a | C(0.004) | |
1 | .a | |||
2 | .a | B(.002) | ||
Lepd2 | 0 | C(0.017) | ||
Lolp1 | 0 | |||
4 | A(0.015) B(0.033) | |||
Lupa | 0 | .a | C(0.002) | |
2 | .a | B(.038) | ||
3 | .a | .a | ||
Mald1 | 0 | C(0.017) | ||
Malas11 | 0 | .a | C(0.001) | |
4 | .a | B(0.008) | ||
Malas6 | 0 | .a | C(0.011) | |
1 | .a | B(0.010) | ||
Mani | 0 | .a | C(0.038) | |
Mera1 | 0 | .a | C(0.035) | |
Musa | 0 | .a | C(0.010) | |
1 | .a | B(0.035) | ||
Oryc2 | 0 | .a | C(0.035) | |
Parj2 | 0 | .a | ||
1 | .a | |||
2 | .a | B(0.029) | ||
Pecspp_ | 0 | |||
1 | ||||
2 | .a | B(0.038) | ||
Penm2 | 0 | C(0.043) | C(0.008) | |
Pera | 0 | C(0.034) | ||
Pera7 | 0 | C(0.030) | ||
Persa | 0 | .a | C(0.002) | |
2 | .a | B(0.010) | ||
Phav | 0 | .a | ||
2 | .a | B(0.010) | ||
Phlp1 | 0 | |||
4 | A(0.044) B(0.044) | |||
Phlp12 | 0 | .a | C(0.022) | |
Phlp2 | 0 | |||
4 | B(0.037) | |||
Phlp5_0101 | 0 | |||
4 | A(0.028) | |||
Phod2 | 0 | .a | C(0.003) | |
3 | .a | B(0.038) | ||
Pima | 0 | .a | C(0.010) | |
1 | .a | B(0.035) | ||
Pyrc | 0 | .a | ||
2 | .a | B(0.038) | ||
Rajc | 0 | .a | .a | .a |
Rudspp_ | 0 | C(0.030) | ||
Sacc | 0 | .a | C(0.011) | |
1 | .a | |||
Salk1 | 0 | .a | C(0.016) | |
Scos | 0 | .a | C(0.035) | |
Secc_flour | 0 | .a | C(0.001) | |
1 | .a | B(0.010) | ||
Sesi | 0 | .a | C(0.035) | |
Sesi1 | 0 | .a | C(0.046) | |
Solt | 0 | .a | C(0.011) | |
Trifo | 0 | .a | C(0.035) | |
Tyrp | 0 | C(0.030) | C(0.002) | |
Tyrp2 | 0 | |||
2 | B(0.029) | |||
Urtd | 0 | .a | C(0.002) | |
1 | .a | B(0.001) | ||
Vesv | 0 | .a | C(0.046) | |
1 | .a | B(0.029) | ||
3 | .a | |||
tIgE | 0 | B(0.001) | .a | |
4 | A(0.001) | .a |
Allergen Reagent, Molecular Components | Group Size | Reach | Pct of Cases | Frequency | Pct of Responses |
---|---|---|---|---|---|
a | |||||
Alng1, Alta1, Betv1, Canf1, Cora1.0103, Cora1.0401, Cora_pollen, Derf2, Derp2, Fags1, Feld1, Lolp1, Phlp1, Phlp2, Phlp5_0101, Phlp6, Secc_pollen, Der p 23 | 18 | 75 | 75.0 | 632 | 85.8 |
b | |||||
Canf4, Artv, Blag9, Cynd, Feld7 | 5 | 52 | 52.0 | 94 | 18 |
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Čelakovská, J.; Bukač, J.; Cermákova, E.; Vaňková, R.; Skalská, H.; Krejsek, J.; Andrýs, C. Analysis of Results of Specific IgE in 100 Atopic Dermatitis Patients with the Use of Multiplex Examination ALEX2—Allergy Explorer. Int. J. Mol. Sci. 2021, 22, 5286. https://doi.org/10.3390/ijms22105286
Čelakovská J, Bukač J, Cermákova E, Vaňková R, Skalská H, Krejsek J, Andrýs C. Analysis of Results of Specific IgE in 100 Atopic Dermatitis Patients with the Use of Multiplex Examination ALEX2—Allergy Explorer. International Journal of Molecular Sciences. 2021; 22(10):5286. https://doi.org/10.3390/ijms22105286
Chicago/Turabian StyleČelakovská, Jarmila, Josef Bukač, Eva Cermákova, Radka Vaňková, Hana Skalská, Jan Krejsek, and Ctirad Andrýs. 2021. "Analysis of Results of Specific IgE in 100 Atopic Dermatitis Patients with the Use of Multiplex Examination ALEX2—Allergy Explorer" International Journal of Molecular Sciences 22, no. 10: 5286. https://doi.org/10.3390/ijms22105286