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Volume 21
Issue 5
10.3390/ijms21051840
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Article
Peer-Review Record

Does the Pre-Ovulatory Pig Oviduct Rule Sperm Capacitation In Vivo Mediating Transcriptomics of Catsper Channels?

Int. J. Mol. Sci. 2020, 21(5), 1840; https://doi.org/10.3390/ijms21051840
by Cristina A. Martinez 1,*, Manuel Alvarez-Rodriguez 1, Dominic Wright 2 and Heriberto Rodriguez-Martinez 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(5), 1840; https://doi.org/10.3390/ijms21051840
Submission received: 15 February 2020 / Revised: 4 March 2020 / Accepted: 5 March 2020 / Published: 7 March 2020
(This article belongs to the Special Issue Advances in Molecular Regulation of Spermatozoa Function)

Round 1

Reviewer 1 Report

This is the weel-planned, well-described and well-discussed report on gene expression pattern changes in the oviduct of pig after semen or semen plasma treatment. For the analysis micrarray chip assay was used.
Before further processing of the manuscript some small modifications are suggested:
1. Minor English correction throughout the ms is needed there is e.g.„whose mechanisms” „responsible of”

2. Abstract-provide full names „Ex-vivo samples of UTJ”

3. Aim „increased knowledge of the molecular patterns present in the oviduct” rather sth like that „the gene pattern and regulated by it molecular processes”
4. Make sure that figures are of proper size as there are many details that can be not well visible in print

Author Response

This is the weel-planned, well-described and well-discussed report on gene expression pattern changes in the oviduct of pig after semen or semen plasma treatment. For the analysis micrarray chip assay was used.

Reply: We thank the reviewer for the nice comments and suggestions.

Before further processing of the manuscript some small modifications are suggested:


  1. Minor English correction throughout the ms is needed there is e.g.„whose mechanisms” „responsible of”

Reply: We have now revised the manuscript and made the corrections mentioned.

  1. Abstract-provide full names „Ex-vivo samples of UTJ”

Reply: We have now added the full name for UTJ in the abstract section.

  1. Aim „increased knowledge of the molecular patterns present in the oviduct” rather sth like that „the gene pattern and regulated by it molecular processes”

Reply: We have changed the sentence.


  1. Make sure that figures are of proper size as there are many details that can be not well visible in print

Reply: We have already made the changes.

Reviewer 2 Report

I think that the results of these studies contributed to partial deciphering the transciptomics of capacitation-related genes in the pig pre-ovulatory oviduct, mediated by semen in an in vivo conditions.

The results of this work especially clearly explain the mechanism and role of Catsper channels in molecular communication between sperm and fallopian tubes.

I have no comments for the authors.

Author Response

We appreciate the comments of the reviewer.

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