Development of an Organ-on-a-Chip-Device for Study of Placental Pathologies
Abstract
:1. Introduction
2. Modeling and Simulation
2.1. Analytical Model and Governing Equations
2.2. Numerical Simulation
3. Results and Discussion
3.1. Cell Culture in the Microfluidic Chip
3.2. Glucose Transport across the Membrane
3.3. Effects of Flow Rate on Glucose Concentration
3.4. Effects of the Membrane Porosity on Glucose Concentration
4. Materials and Methods
4.1. Cell Culture
4.2. Microchip Design and Fabrication
4.3. Microfluidic Cell Culture
4.4. Placental Barrier Permeability and Diffusion Rate
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Mosavati, B.; Oleinikov, A.V.; Du, E. Development of an Organ-on-a-Chip-Device for Study of Placental Pathologies. Int. J. Mol. Sci. 2020, 21, 8755. https://doi.org/10.3390/ijms21228755
Mosavati B, Oleinikov AV, Du E. Development of an Organ-on-a-Chip-Device for Study of Placental Pathologies. International Journal of Molecular Sciences. 2020; 21(22):8755. https://doi.org/10.3390/ijms21228755
Chicago/Turabian StyleMosavati, Babak, Andrew V. Oleinikov, and E. Du. 2020. "Development of an Organ-on-a-Chip-Device for Study of Placental Pathologies" International Journal of Molecular Sciences 21, no. 22: 8755. https://doi.org/10.3390/ijms21228755