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Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases

1
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konyang University, Daejeon 35365, Korea
2
Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon 35365, Korea
3
Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan 54538, Korea
4
Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
5
Institute for Glycoscience, Wonkwang University, Iksan 54538, Korea
6
College of Medicine, Dongguk University, Goyang 10326, Korea
7
Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(21), 8366; https://doi.org/10.3390/ijms21218366
Received: 12 October 2020 / Revised: 29 October 2020 / Accepted: 5 November 2020 / Published: 7 November 2020
(This article belongs to the Section Biochemistry)
Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated from various tissues in the adult body. MSCs should be characterized by three criteria for regenerative medicine. MSCs must (1) adhere to plastic surfaces, (2) express specific surface antigens, and (3) differentiate into mesodermal lineages, including chondrocytes, osteoblasts, and adipocytes, in vitro. Interestingly, MSCs have immunomodulatory features and secrete trophic factors and immune receptors that regulate the microenvironment in host tissue. These specific and unique therapeutic properties make MSCs ideal as therapeutic agents in vivo. Specifically, pre-clinical and clinical investigators generated inflammatory and fibrotic diseases models, and then transplantation of MSCs into diseases models for therapeutic effects investigation. In this review, we characterize MSCs from various tissues and describe their applications for treating various inflammation and fibrotic diseases. View Full-Text
Keywords: mesenchymal stem cells (MSCs); paracrine factors; inflammatory disease; fibrotic disease mesenchymal stem cells (MSCs); paracrine factors; inflammatory disease; fibrotic disease
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MDPI and ACS Style

Ryu, J.-S.; Jeong, E.-J.; Kim, J.-Y.; Park, S.J.; Ju, W.S.; Kim, C.-H.; Kim, J.-S.; Choo, Y.-K. Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases. Int. J. Mol. Sci. 2020, 21, 8366. https://doi.org/10.3390/ijms21218366

AMA Style

Ryu J-S, Jeong E-J, Kim J-Y, Park SJ, Ju WS, Kim C-H, Kim J-S, Choo Y-K. Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases. International Journal of Molecular Sciences. 2020; 21(21):8366. https://doi.org/10.3390/ijms21218366

Chicago/Turabian Style

Ryu, Jae-Sung, Eun-Jeong Jeong, Jong-Yeup Kim, Soon J. Park, Won S. Ju, Chang-Hyun Kim, Jang-Seong Kim, and Young-Kug Choo. 2020. "Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases" International Journal of Molecular Sciences 21, no. 21: 8366. https://doi.org/10.3390/ijms21218366

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