18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress
Abstract
:1. Introduction
2. Results
2.1. Effect of STZ on Serum Glucose Levels and Brain FDG Kinetics
2.2. Evaluation of Enzymatic Catalytic Functions
2.3. Regional Heterogeneity of the Hyperglycemia-Related Redox Damage
2.4. FDG Uptake Heterogeneity Tracks the Divergent ER-PPP Antioxidant Response to the Hyperglycemia-Related Redox Damage
3. Discussion
4. Materials and Methods
4.1. In Vivo Study Protocol
4.2. Micro-PET Imaging Protocol and Image Processing
4.3. Histochemical Analysis
4.4. Spectrophotometric Assays
4.5. Western Blot Analysis
4.6. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Miceli, A.; Cossu, V.; Marini, C.; Castellani, P.; Raffa, S.; Donegani, M.I.; Bruno, S.; Ravera, S.; Emionite, L.; Orengo, A.M.; et al. 18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress. Int. J. Mol. Sci. 2020, 21, 8154. https://doi.org/10.3390/ijms21218154
Miceli A, Cossu V, Marini C, Castellani P, Raffa S, Donegani MI, Bruno S, Ravera S, Emionite L, Orengo AM, et al. 18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress. International Journal of Molecular Sciences. 2020; 21(21):8154. https://doi.org/10.3390/ijms21218154
Chicago/Turabian StyleMiceli, Alberto, Vanessa Cossu, Cecilia Marini, Patrizia Castellani, Stefano Raffa, Maria Isabella Donegani, Silvia Bruno, Silvia Ravera, Laura Emionite, Anna Maria Orengo, and et al. 2020. "18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress" International Journal of Molecular Sciences 21, no. 21: 8154. https://doi.org/10.3390/ijms21218154