Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids
Abstract
:1. Introduction
2. Results and Discussion
2.1. Localized Irradiation of Spheroids
2.2. Combination Therapy in 3D Models–Dox and Localized Photothermy Mediated by AuNP@PEG
3. Materials and Methods
3.1. Gold Nanoparticles Synthesis, Functionalization and Characterization
3.2. Cell Cultures and Cell Cultures Maintenance
3.3. Spheroids Preparation and Handling
3.4. Spheroids Irradiation
3.5. Cell Viability
3.6. Effect of Doxorubicin
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Roma-Rodrigues, C.; Pombo, I.; Fernandes, A.R.; Baptista, P.V. Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids. Int. J. Mol. Sci. 2020, 21, 8017. https://doi.org/10.3390/ijms21218017
Roma-Rodrigues C, Pombo I, Fernandes AR, Baptista PV. Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids. International Journal of Molecular Sciences. 2020; 21(21):8017. https://doi.org/10.3390/ijms21218017
Chicago/Turabian StyleRoma-Rodrigues, Catarina, Inês Pombo, Alexandra R. Fernandes, and Pedro V. Baptista. 2020. "Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids" International Journal of Molecular Sciences 21, no. 21: 8017. https://doi.org/10.3390/ijms21218017