NAA10 as a New Prognostic Marker for Cancer Progression
Abstract
:1. Introduction
2. NATs
3. NAA10
4. Expression of NAA10 in Cancer
4.1. Breast Cancer (BCa)
4.2. Lung Cancer (LCa)
4.3. Hepatocellular Carcinoma (HCC)
4.4. Colorectal Cancer (CRC)
4.5. Osteosarcoma
4.6. Oral Squamous Cell Carcinoma (OSCC)
4.7. Prostate Cancer (PCa)
5. NAA10 as a Prognostic Marker
5.1. NAA10 and Cancer Survival
5.1.1. BCa
5.1.2. LCa
5.1.3. HCC
5.1.4. CRC
5.1.5. Osteosarcoma
5.1.6. OSCC
5.2. Invasion and Metastasis
5.2.1. BCa
5.2.2. LCa
5.2.3. HCC
5.2.4. Osteosarcoma
5.2.5. OSCC
5.3. Recurrence
6. NAA10 in Tumorigenesis
6.1. NAA10 as an Oncoprotein
6.2. NAA10 as a Tumor Suppressor
7. Other NATs in Cancer
8. Conclusions and Perspectives
Author Contributions
Funding
Conflicts of Interest
Abbreviations
AIF | Apoptosis-inducing factor |
Apaf-1 | Apoptotic protease-activating factor-1 |
AR | Androgen receptor |
ARD1 | Arrest-defective 1 |
ATD | Acetyltransferase domain |
AuA | Aurora kinase A |
BCa | Breast cancer |
CRC | Colorectal cancer |
DNMT1 | DNA methyltransferase 1 |
FIH | Factor Inhibiting HIF |
HCC | Hepatocellular carcinoma |
Hsp70 | Heat shock protein 70 |
HYPK | Huntingtin yeast two-hybrid protein K |
IDC | Invasive ductal carcinoma |
IDR | Intrinsically disordered region |
IKKβ | IκB kinase β |
KAT | Lysine acetyltransferase |
KDAC | Lysine deacetylase |
LCa | Lung cancer |
MLCK | Myosin light chain kinase |
MMP-2 | Matrix metalloproteinase-2 |
MVI | Microvascular invasion |
NAA10 | N-α-acetyltransferase 10 |
NAT | N-terminal acetyltransferase |
OSCC | Oral squamous cell carcinoma |
PGK1 | Phosphoglycerate kinase 1 |
PIX | p21-activated kinase-interacting exchange factor |
PCa | Prostate cancer |
Runx2 | Runt-related transcription factor 2 |
STAT5α | Signal transducer and activator of transcription 5α |
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Prognosis | Cancer Type | Clinical Outcome | Reference |
---|---|---|---|
Overall Survival | Breast cancer | Low | Wang et al., 2011 [4] |
High | Kuo et al., 2010 [37] | ||
High | Zeng et al., 2014 [51] | ||
Colon cancer | Low | Jiang et al., 2010 [6] | |
HCC | Low | Lee et al., 2018 [19] | |
Lung cancer | Low | Lee et al., 2010 [8] | |
High | Hua et al., 2011 [38] | ||
OSCC | High | Zeng et al., 2016 [46] | |
Osteosarcoma | Low | Chien et al., 2018 [5] | |
Invasiveness | HCC | MVI | Shim et al., 2012 [7] |
Metastasis | Breast cancer | High | Wang et al., 2011 [4] |
Low | Kuo et al., 2010 [37] | ||
Low | Zeng et al., 2011 [51] | ||
Lung cancer | Low | Hua et al., 2011 [38] | |
OSCC | Low | Zeng et al., 2016 [46] | |
Osteosarcoma | High | Chien et al., 2018 [5] | |
Recurrence | Breast cancer | High | Wang et al., 2011 [4] |
HCC | High | Lee et al., 2018 [19] | |
OSCC | Low | Zeng et al., 2016 [46] |
Role | Target Protein | Function | Effect of NAA10 | Activity | Reference |
---|---|---|---|---|---|
Oncoprotein | β-catenin | Proliferation | Acetylation | Activated | Lim et al., 2016 [6] |
Cdc25A | Proliferation | Acetylation | Activated | Lozada et al., 2016 [52] | |
AR | Proliferation | Acetylation | Activated | DePaolo et al., 2016 [22] | |
PGK1 | Autophagy | Acetylation at K388 | Activated | Qian et al., 2017 [25] | |
Hsp70 | Apoptosis | Acetylation at K77 | Activated | Park et al., 2017 [53] | |
DNMT1 | Migration | Interaction | Activated | Lee et al., 2010 [8] | |
AuA | Migration | Acetylation at K75/K125 | Activated | Vo et al., 2017 [54] | |
MMP-2 | Migration | Stabilization | Activated | Chien et al., 2018 [5] | |
Tumor suppressor | TSC2 | Autophagy | Acetylation | Activated | Kuo et al., 2010 [37] |
MLCK | Migration | Acetylation at K608 | Inactivated | Shin et al., 2009 [55] | |
PIX | Migration | Interaction | Inactivated | Hua et al., 2011 [38] | |
STAT5α | Migration | Interaction | Inactivated | Zeng et al., 2014 [51] |
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Kim, S.M.; Ha, E.; Kim, J.; Cho, C.; Shin, S.-J.; Seo, J.H. NAA10 as a New Prognostic Marker for Cancer Progression. Int. J. Mol. Sci. 2020, 21, 8010. https://doi.org/10.3390/ijms21218010
Kim SM, Ha E, Kim J, Cho C, Shin S-J, Seo JH. NAA10 as a New Prognostic Marker for Cancer Progression. International Journal of Molecular Sciences. 2020; 21(21):8010. https://doi.org/10.3390/ijms21218010
Chicago/Turabian StyleKim, Sun Myung, Eunyoung Ha, Jinyoung Kim, Chiheum Cho, So-Jin Shin, and Ji Hae Seo. 2020. "NAA10 as a New Prognostic Marker for Cancer Progression" International Journal of Molecular Sciences 21, no. 21: 8010. https://doi.org/10.3390/ijms21218010