Targeting DNA Repair Pathways in Hematological Malignancies
1
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan
2
College of Medicine, QU Health, Qatar University, P. O. Box 2713 Doha, Qatar
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7365; https://doi.org/10.3390/ijms21197365
Received: 3 September 2020 / Revised: 25 September 2020 / Accepted: 1 October 2020 / Published: 6 October 2020
(This article belongs to the Special Issue DNA Repair in Cancers)
DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple genomic changes that ultimately may result in mutation, tumor growth, and/or cell apoptosis. Furthermore, impaired repair mechanisms can also lead to genomic instability, which can initiate tumorigenesis and development of hematological malignancy. This review discusses recent findings and highlights the importance of DNA repair components and the impact of their aberrations on hematological malignancies.
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Keywords:
DNA repair; DNA damage; hematological malignancies; apoptosis; mutation
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MDPI and ACS Style
Alhmoud, J.F.; Mustafa, A.G.; Malki, M.I. Targeting DNA Repair Pathways in Hematological Malignancies. Int. J. Mol. Sci. 2020, 21, 7365. https://doi.org/10.3390/ijms21197365
AMA Style
Alhmoud JF, Mustafa AG, Malki MI. Targeting DNA Repair Pathways in Hematological Malignancies. International Journal of Molecular Sciences. 2020; 21(19):7365. https://doi.org/10.3390/ijms21197365
Chicago/Turabian StyleAlhmoud, Jehad F.; Mustafa, Ayman G.; Malki, Mohammed I. 2020. "Targeting DNA Repair Pathways in Hematological Malignancies" Int. J. Mol. Sci. 21, no. 19: 7365. https://doi.org/10.3390/ijms21197365
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