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The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy

1
College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea
2
Department of Biomedical Sciences, Chonnam National University Medical School, 322 Seoyang-ro, Hwasun 58128, Korea
3
Department of Chemical and Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Chungju, Chungbuk 27469, Korea
4
College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea
5
Department of Biomedical Sciences, Graduate School, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7363; https://doi.org/10.3390/ijms21197363
Received: 29 August 2020 / Revised: 30 September 2020 / Accepted: 3 October 2020 / Published: 5 October 2020
(This article belongs to the Special Issue Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics)
Cancer therapeutics must be delivered to their targets for improving efficacy and reducing toxicity, though they encounter physiological barriers in the tumor microenvironment. They also face limitations associated with genetic instability and dynamic changes of surface proteins in cancer cells. Nanosized exosomes generated from the endosomal compartment, however, transfer their cargo to the recipient cells and mediate the intercellular communication, which affects malignancy progression, tumor immunity, and chemoresistance. In this review, we give an overview of exosomes’ biological aspects and therapeutic potential as diagnostic biomarkers and drug delivery vehicles for oncotherapy. Furthermore, we discuss whether exosomes could contribute to personalized cancer immunotherapy drug design as efficient nanocommunicators. View Full-Text
Keywords: exosome; cancer; nanocommunicator; diagnostic biomarker; drug delivery vehicle; personalized cancer immunotherapy exosome; cancer; nanocommunicator; diagnostic biomarker; drug delivery vehicle; personalized cancer immunotherapy
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MDPI and ACS Style

Choi, J.U.; Park, I.-K.; Lee, Y.-K.; Hwang, S.R. The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy. Int. J. Mol. Sci. 2020, 21, 7363. https://doi.org/10.3390/ijms21197363

AMA Style

Choi JU, Park I-K, Lee Y-K, Hwang SR. The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy. International Journal of Molecular Sciences. 2020; 21(19):7363. https://doi.org/10.3390/ijms21197363

Chicago/Turabian Style

Choi, Jeong U., In-Kyu Park, Yong-Kyu Lee, and Seung R. Hwang. 2020. "The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy" International Journal of Molecular Sciences 21, no. 19: 7363. https://doi.org/10.3390/ijms21197363

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