Next Article in Journal
In Vivo Studies of Inoculated Plants and In Vitro Studies Utilizing Methanolic Extracts of Endophytic Streptomyces sp. Strain DBT34 Obtained from Mirabilis jalapa L. Exhibit ROS-Scavenging and Other Bioactive Properties
Next Article in Special Issue
Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer
Previous Article in Journal
Gene Editing by Extracellular Vesicles
Previous Article in Special Issue
More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer
Open AccessReview

The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy

1
College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea
2
Department of Biomedical Sciences, Chonnam National University Medical School, 322 Seoyang-ro, Hwasun 58128, Korea
3
Department of Chemical and Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Chungju, Chungbuk 27469, Korea
4
College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea
5
Department of Biomedical Sciences, Graduate School, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7363; https://doi.org/10.3390/ijms21197363
Received: 29 August 2020 / Revised: 30 September 2020 / Accepted: 3 October 2020 / Published: 5 October 2020
(This article belongs to the Special Issue Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics)
Cancer therapeutics must be delivered to their targets for improving efficacy and reducing toxicity, though they encounter physiological barriers in the tumor microenvironment. They also face limitations associated with genetic instability and dynamic changes of surface proteins in cancer cells. Nanosized exosomes generated from the endosomal compartment, however, transfer their cargo to the recipient cells and mediate the intercellular communication, which affects malignancy progression, tumor immunity, and chemoresistance. In this review, we give an overview of exosomes’ biological aspects and therapeutic potential as diagnostic biomarkers and drug delivery vehicles for oncotherapy. Furthermore, we discuss whether exosomes could contribute to personalized cancer immunotherapy drug design as efficient nanocommunicators. View Full-Text
Keywords: exosome; cancer; nanocommunicator; diagnostic biomarker; drug delivery vehicle; personalized cancer immunotherapy exosome; cancer; nanocommunicator; diagnostic biomarker; drug delivery vehicle; personalized cancer immunotherapy
Show Figures

Figure 1

MDPI and ACS Style

Choi, J.U.; Park, I.-K.; Lee, Y.-K.; Hwang, S.R. The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy. Int. J. Mol. Sci. 2020, 21, 7363.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop