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The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides

1
Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
2
Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
3
Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, 09124 Cagliari, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7349; https://doi.org/10.3390/ijms21197349
Received: 31 August 2020 / Revised: 23 September 2020 / Accepted: 25 September 2020 / Published: 5 October 2020
(This article belongs to the Special Issue Creation of New Antimicrobial Peptides)
Health-care systems that develop rapidly and efficiently may increase the lifespan of humans. Nevertheless, the older population is more fragile, and is at an increased risk of disease development. A concurrently growing number of surgeries and transplantations have caused antibiotics to be used much more frequently, and for much longer periods of time, which in turn increases microbial resistance. In 1945, Fleming warned against the abuse of antibiotics in his Nobel lecture: “The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant”. After 70 years, we are witnessing the fulfilment of Fleming’s prophecy, as more than 700,000 people die each year due to drug-resistant diseases. Naturally occurring antimicrobial peptides protect all living matter against bacteria, and now different peptidomimetic strategies to engineer innovative antibiotics are being developed to defend humans against bacterial infections. View Full-Text
Keywords: antimicrobial peptides; antibiotics; peptidomimetics; polymers; metal coplexes antimicrobial peptides; antibiotics; peptidomimetics; polymers; metal coplexes
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MDPI and ACS Style

Lachowicz, J.I.; Szczepski, K.; Scano, A.; Casu, C.; Fais, S.; Orrù, G.; Pisano, B.; Piras, M.; Jaremko, M. The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides. Int. J. Mol. Sci. 2020, 21, 7349. https://doi.org/10.3390/ijms21197349

AMA Style

Lachowicz JI, Szczepski K, Scano A, Casu C, Fais S, Orrù G, Pisano B, Piras M, Jaremko M. The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides. International Journal of Molecular Sciences. 2020; 21(19):7349. https://doi.org/10.3390/ijms21197349

Chicago/Turabian Style

Lachowicz, Joanna I.; Szczepski, Kacper; Scano, Alessandra; Casu, Cinzia; Fais, Sara; Orrù, Germano; Pisano, Barbara; Piras, Monica; Jaremko, Mariusz. 2020. "The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides" Int. J. Mol. Sci. 21, no. 19: 7349. https://doi.org/10.3390/ijms21197349

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