Review Reports

Round 1

Reviewer 1 Report

Authors successfully reviewed the value and significance of IPs in the fine control of PI3K signaling. The only concern that I found is the ignorance of the following paper showing that 5-IP7 acts as a high-affinity inositol phosphate to inhibit Akt via binding to its PH domain. Authors should include the key discoveries of 5-IP7 actions in Akt control. Cell. 2010 Dec 10; 143(6): 897–910. Inositol pyrophosphates inhibit Akt signaling, regulate insulin sensitivity and weight gain

Author Response

This is a good point and we have added the citation suggested 

Reviewer 2 Report

This manuscript well descript about PI3K inhibitor compounds.

Author Response

We have revised the manuscript and corrected all grammar and spelling mistakes as suggested