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Review
Peer-Review Record

Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling

Int. J. Mol. Sci. 2020, 21(19), 7198; https://doi.org/10.3390/ijms21197198
by Tania Maffucci 1,* and Marco Falasca 2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(19), 7198; https://doi.org/10.3390/ijms21197198
Submission received: 8 August 2020 / Revised: 21 September 2020 / Accepted: 21 September 2020 / Published: 29 September 2020
(This article belongs to the Special Issue Phosphoinositides and Downstream Signalling Molecules)

Round 1

Reviewer 1 Report

Authors successfully reviewed the value and significance of IPs in the fine control of PI3K signaling. The only concern that I found is the ignorance of the following paper showing that 5-IP7 acts as a high-affinity inositol phosphate to inhibit Akt via binding to its PH domain. Authors should include the key discoveries of 5-IP7 actions in Akt control. Cell. 2010 Dec 10; 143(6): 897–910. Inositol pyrophosphates inhibit Akt signaling, regulate insulin sensitivity and weight gain

Author Response

This is a good point and we have added the citation suggested 

Reviewer 2 Report

This manuscript well descript about PI3K inhibitor compounds.

Author Response

We have revised the manuscript and corrected all grammar and spelling mistakes as suggested 

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