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Review

Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents—Pathophysiology and Biomarkers—A Review

1
Department of Internal Medicine, University Hospital Ostrava, 70852 Ostrava, Czech Republic
2
Department of Clinical Studies Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic
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Department of Internal Medicine III—Nephrology, Rheumatology and Endocrinology, University Hospital and Faculty of Medicine and Dentistry, Palacky University Olomouc, 77900 Olomouc, Czech Republic
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Department of Anesthesiology and Resuscitation, University Hospital Ostrava, 70852 Ostrava, Czech Republic
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Department of Laboratory Diagnostics Institute of Clinical Biochemistry and Clinical Pharmacology, University Hospital Ostrava, 70852 Ostrava, Czech Republic
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Department of Biomedical Sciences Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic
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Institute of Clinical Pharmacology Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7115; https://doi.org/10.3390/ijms21197115
Received: 23 August 2020 / Revised: 24 September 2020 / Accepted: 25 September 2020 / Published: 26 September 2020
(This article belongs to the Special Issue Biomarkers of Renal Diseases)
Acute kidney injury is a common complication in critically ill patients with sepsis and/or septic shock. Further, some essential antimicrobial treatment drugs are themselves nephrotoxic. For this reason, timely diagnosis and adequate therapeutic management are paramount. Of potential acute kidney injury (AKI) biomarkers, non-protein-coding RNAs are a subject of ongoing research. This review covers the pathophysiology of vancomycin and gentamicin nephrotoxicity in particular, septic AKI and the microRNAs involved in the pathophysiology of both syndromes. PubMED, UptoDate, MEDLINE and Cochrane databases were searched, using the terms: biomarkers, acute kidney injury, antibiotic nephrotoxicity, sepsis, miRNA and nephrotoxicity. A comprehensive review describing pathophysiology and potential biomarkers of septic and toxic acute kidney injury in septic patients was conducted. In addition, five miRNAs: miR-15a-5p, miR-192-5p, miR-155-5p, miR-486-5p and miR-423-5p specific to septic and toxic acute kidney injury in septic patients, treated by nephrotoxic antibiotic agents (vancomycin and gentamicin) were identified. However, while these are at the stage of clinical testing, preclinical and clinical trials are needed before they can be considered useful biomarkers or therapeutic targets of AKI in the context of antibiotic nephrotoxicity or septic injury. View Full-Text
Keywords: acute kidney injury; gentamicin; sepsis; miRNA; nephrotoxicity; vancomycin acute kidney injury; gentamicin; sepsis; miRNA; nephrotoxicity; vancomycin
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MDPI and ACS Style

Petejova, N.; Martinek, A.; Zadrazil, J.; Kanova, M.; Klementa, V.; Sigutova, R.; Kacirova, I.; Hrabovsky, V.; Svagera, Z.; Stejskal, D. Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents—Pathophysiology and Biomarkers—A Review. Int. J. Mol. Sci. 2020, 21, 7115. https://doi.org/10.3390/ijms21197115

AMA Style

Petejova N, Martinek A, Zadrazil J, Kanova M, Klementa V, Sigutova R, Kacirova I, Hrabovsky V, Svagera Z, Stejskal D. Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents—Pathophysiology and Biomarkers—A Review. International Journal of Molecular Sciences. 2020; 21(19):7115. https://doi.org/10.3390/ijms21197115

Chicago/Turabian Style

Petejova, Nadezda, Arnost Martinek, Josef Zadrazil, Marcela Kanova, Viktor Klementa, Radka Sigutova, Ivana Kacirova, Vladimir Hrabovsky, Zdenek Svagera, and David Stejskal. 2020. "Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents—Pathophysiology and Biomarkers—A Review" International Journal of Molecular Sciences 21, no. 19: 7115. https://doi.org/10.3390/ijms21197115

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