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Review

How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1

by
Jingyu Qin
1,
Hui Zhang
2,
Yizhao Geng
2,3,* and
Qing Ji
2,3,*
1
College of Education, Shanghai Normal University, Shanghai 200234, China
2
School of Science, Hebei University of Technology, Tianjin 300401, China
3
Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6977; https://doi.org/10.3390/ijms21186977
Submission received: 4 August 2020 / Revised: 12 September 2020 / Accepted: 21 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Molecular Motors: From Single Molecules to Cooperative and Regulatory Mechanisms In Vivo)
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Abstract

Kinesin-1 is a typical motile molecular motor and the founding member of the kinesin family. The most significant feature in the unidirectional motion of kinesin-1 is its processivity. To realize the fast and processive movement on the microtubule lattice, kinesin-1 efficiently transforms the chemical energy of nucleotide binding and hydrolysis to the energy of mechanical movement. The chemical and mechanical cycle of kinesin-1 are coupled to avoid futile nucleotide hydrolysis. In this paper, the research on the mechanical pathway of energy transition and the regulating mechanism of the mechanochemical cycle of kinesin-1 is reviewed.
Keywords: Kinesin-1; nucleotide; microtubule; mechanochemical coupling; neck linker; conformational change Kinesin-1; nucleotide; microtubule; mechanochemical coupling; neck linker; conformational change

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MDPI and ACS Style

Qin, J.; Zhang, H.; Geng, Y.; Ji, Q. How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1. Int. J. Mol. Sci. 2020, 21, 6977. https://doi.org/10.3390/ijms21186977

AMA Style

Qin J, Zhang H, Geng Y, Ji Q. How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1. International Journal of Molecular Sciences. 2020; 21(18):6977. https://doi.org/10.3390/ijms21186977

Chicago/Turabian Style

Qin, Jingyu, Hui Zhang, Yizhao Geng, and Qing Ji. 2020. "How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1" International Journal of Molecular Sciences 21, no. 18: 6977. https://doi.org/10.3390/ijms21186977

APA Style

Qin, J., Zhang, H., Geng, Y., & Ji, Q. (2020). How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1. International Journal of Molecular Sciences, 21(18), 6977. https://doi.org/10.3390/ijms21186977

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