Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease
1
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
2
Gregory Fleming James Cystic Fibrosis Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6924; https://doi.org/10.3390/ijms21186924
Received: 5 August 2020
/
Revised: 5 September 2020
/
Accepted: 15 September 2020
/
Published: 21 September 2020
(This article belongs to the Special Issue Therapeutic Approaches for Aging-Related Lung Disease)
Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the third leading cause of death worldwide. COPD is characterized by chronic airway inflammation, loss of alveolar-capillary units, and progressive decline in lung function. Major risk factors for COPD are cigarette smoking and aging. COPD-associated pathomechanisms include multiple aging pathways such as telomere attrition, epigenetic alterations, altered nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell exhaustion and chronic inflammation. In this review, we will highlight the current literature that focuses on the role of age and aging-associated signaling pathways as well as their impact on current treatment strategies in the pathogenesis of COPD. Furthermore, we will discuss established and experimental COPD treatments including senolytic and anti-aging therapies and their potential use as novel treatment strategies in COPD.
View Full-Text
Keywords:
COPD; aging; senescence; inflammation; senolytics; cigarette smoke
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Easter, M.; Bollenbecker, S.; Barnes, J.W.; Krick, S. Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease. Int. J. Mol. Sci. 2020, 21, 6924. https://doi.org/10.3390/ijms21186924
AMA Style
Easter M, Bollenbecker S, Barnes JW, Krick S. Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease. International Journal of Molecular Sciences. 2020; 21(18):6924. https://doi.org/10.3390/ijms21186924
Chicago/Turabian StyleEaster, Molly, Seth Bollenbecker, Jarrod W. Barnes, and Stefanie Krick. 2020. "Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease" International Journal of Molecular Sciences 21, no. 18: 6924. https://doi.org/10.3390/ijms21186924
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
