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Review

Deciphering SARS-CoV-2 Virologic and Immunologic Features

1
Unité de Recherche Études Pharmaco-Immunologiques, Centre Hospitalier Universitaire La Réunion Site Félix Guyon, CS11021, 97400 Saint Denis de La Réunion, France
2
Laboratoire de Biologie, Secteur Laboratoire d’immunologie Clinique et Expérimentale de la Zone de l’océan Indien (LICE-OI), Centre Hospitalier Universitaire La Réunion Site Félix Guyon, CS11021, 97400 Saint Denis de La Réunion, France
3
Unité Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion, INSERM UMR 1187, CNRS 9192, IRD 249, Platform CYROI, 2 rue Maxime Rivière, 97491 Sainte Clotilde, La Réunion, France
4
Service d’anatomo-Pathologie, Centre Hospitalier Universitaire Sud Réunion, 97410 Saint Pierre, France
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Service de Rhumatologie, Centre Hospitalier Universitaire La Réunion Site Félix Guyon, CS11021, 97400 Saint Denis de La Réunion, France
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Service d’endocrinologie Diabétologie, Centre Hospitalier Universitaire Sud Réunion, 97410 Saint Pierre, France
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Université de Formation et de Recherche Santé, Université de la Réunion, 97400 Saint-Denis, France
8
Service de Médecine Interne, Centre Hospitalier Universitaire La Réunion Site Félix Guyon, CS11021, 97400 Saint Denis de La Réunion, France
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(16), 5932; https://doi.org/10.3390/ijms21165932
Received: 19 June 2020 / Revised: 11 August 2020 / Accepted: 14 August 2020 / Published: 18 August 2020
(This article belongs to the Section Molecular Immunology)
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and its associated pathology, COVID-19, have been of particular concerns these last months due to the worldwide burden they represent. The number of cases requiring intensive care being the critical point in this epidemic, a better understanding of the pathophysiology leading to these severe cases is urgently needed. Tissue lesions can be caused by the pathogen or can be driven by an overwhelmed immune response. Focusing on SARS-CoV-2, we and others have observed that this virus can trigger indeed an immune response that can be dysregulated in severe patients and leading to further injury to multiple organs. The purpose of the review is to bring to light the current knowledge about SARS-CoV-2 virologic and immunologic features. Thus, we address virus biology, life cycle, tropism for many organs and how ultimately it will affect several host biological and physiological functions, notably the immune response. Given that therapeutic avenues are now highly warranted, we also discuss the immunotherapies available to manage the infection and the clinical outcomes. View Full-Text
Keywords: SARS-CoV-2; COVID-19; virus biology; immunopathology; immunotherapy SARS-CoV-2; COVID-19; virus biology; immunopathology; immunotherapy
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MDPI and ACS Style

Lebeau, G.; Vagner, D.; Frumence, É.; Ah-Pine, F.; Guillot, X.; Nobécourt, E.; Raffray, L.; Gasque, P. Deciphering SARS-CoV-2 Virologic and Immunologic Features. Int. J. Mol. Sci. 2020, 21, 5932. https://doi.org/10.3390/ijms21165932

AMA Style

Lebeau G, Vagner D, Frumence É, Ah-Pine F, Guillot X, Nobécourt E, Raffray L, Gasque P. Deciphering SARS-CoV-2 Virologic and Immunologic Features. International Journal of Molecular Sciences. 2020; 21(16):5932. https://doi.org/10.3390/ijms21165932

Chicago/Turabian Style

Lebeau, Grégorie, Damien Vagner, Étienne Frumence, Franck Ah-Pine, Xavier Guillot, Estelle Nobécourt, Loïc Raffray, and Philippe Gasque. 2020. "Deciphering SARS-CoV-2 Virologic and Immunologic Features" International Journal of Molecular Sciences 21, no. 16: 5932. https://doi.org/10.3390/ijms21165932

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