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The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species

Research Center for Advanced Medicine-Medfuture, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
The Blood Bank, Landspitali University Hospital, 121 Reykjavik, Iceland
School of Science and Engineering, Reykjavik University, 107 Reykjavik, Iceland
Department of Hematology, Oncology Institute Prof. Dr. Ion Chiricuta, 400015 Cluj-Napoca, Romania
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5866;
Received: 10 July 2020 / Revised: 12 August 2020 / Accepted: 13 August 2020 / Published: 15 August 2020
(This article belongs to the Special Issue Exosomes in Cancer Diagnosis and Therapy)
Nowadays, advancements in the oncology sector regarding diagnosis methods allow us to specifically detect an increased number of cancer patients, some of them in incipient stages. However, one of the main issues consists of the invasive character of most of the diagnosis protocols or complex medical procedures associated with it, that impedes part of the patients to undergo routine checkups. Therefore, in order to increase the number of cancer cases diagnosed in incipient stages, other minimally invasive alternatives must be considered. The current review paper presents the value of rare RNA species isolated from circulatory exosomes as biomarkers of diagnosis, prognosis or even therapeutic intervention. Rare RNAs are most of the time overlooked in current research in favor of the more abundant RNA species like microRNAs. However, their high degree of stability, low variability and, for most of them, conservation across species could shift the interest toward these types of RNAs. Moreover, due to their low abundance, the variation interval in terms of the number of sequences with differential expression between samples from healthy individuals and cancer patients is significantly diminished and probably easier to interpret in a clinical context. View Full-Text
Keywords: exosomes; snRNA; snoRNA; piRNA; vRNA; yRNA; tRNA; cancer exosomes; snRNA; snoRNA; piRNA; vRNA; yRNA; tRNA; cancer
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MDPI and ACS Style

Zimta, A.-A.; Sigurjonsson, O.E.; Gulei, D.; Tomuleasa, C. The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species. Int. J. Mol. Sci. 2020, 21, 5866.

AMA Style

Zimta A-A, Sigurjonsson OE, Gulei D, Tomuleasa C. The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species. International Journal of Molecular Sciences. 2020; 21(16):5866.

Chicago/Turabian Style

Zimta, Alina-Andreea, Olafur E. Sigurjonsson, Diana Gulei, and Ciprian Tomuleasa. 2020. "The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species" International Journal of Molecular Sciences 21, no. 16: 5866.

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