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Review

Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?

Unité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, Belgium
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Int. J. Mol. Sci. 2020, 21(13), 4767; https://doi.org/10.3390/ijms21134767
Received: 27 May 2020 / Revised: 30 June 2020 / Accepted: 1 July 2020 / Published: 4 July 2020
Pancreatic cancer is a very aggressive cancer type associated with one of the poorest prognostics. Despite several clinical trials to combine different types of therapies, none of them resulted in significant improvements for patient survival. Pancreatic cancers demonstrate a very broad panel of resistance mechanisms due to their biological properties but also their ability to remodel the tumour microenvironment. Radiotherapy is one of the most widely used treatments against cancer but, up to now, its impact remains limited in the context of pancreatic cancer. The modern era of radiotherapy proposes new approaches with increasing conformation but also more efficient effects on tumours in the case of charged particles. In this review, we highlight the interest in using charged particles in the context of pancreatic cancer therapy and the impact of this alternative to counteract resistance mechanisms. View Full-Text
Keywords: pancreatic cancer; protons; carbon ions; radioresistance; chemoresistance; targeted combination; immunotherapy pancreatic cancer; protons; carbon ions; radioresistance; chemoresistance; targeted combination; immunotherapy
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MDPI and ACS Style

Huart, C.; Chen, J.-W.; Le Calvé, B.; Michiels, C.; Wéra, A.-C. Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? Int. J. Mol. Sci. 2020, 21, 4767. https://doi.org/10.3390/ijms21134767

AMA Style

Huart C, Chen J-W, Le Calvé B, Michiels C, Wéra A-C. Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? International Journal of Molecular Sciences. 2020; 21(13):4767. https://doi.org/10.3390/ijms21134767

Chicago/Turabian Style

Huart, Camille, Jia-Wei Chen, Benjamin Le Calvé, Carine Michiels, and Anne-Catherine Wéra. 2020. "Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?" International Journal of Molecular Sciences 21, no. 13: 4767. https://doi.org/10.3390/ijms21134767

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